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Article: Pillars Article: Requirement for the Transcription Factor LSIRF/IRF4 for Mature B and T Lymphocyte Function. Science. 1997. 275: 540–543

TitlePillars Article: Requirement for the Transcription Factor LSIRF/IRF4 for Mature B and T Lymphocyte Function. Science. 1997. 275: 540–543
Authors
Issue Date2017
PublisherThe American Association of Immunologists, Inc. The Journal's web site is located at https://www.jimmunol.org/
Citation
Journal of Immunology, 2017, v. 199, n. 11, p. 3717-3720 How to Cite?
AbstractLymphocyte-specific interferon regulatory factor (LSIRF) (now called IRF4) is a transcription factor expressed only in lymphocytes. Mice deficient in IRF4 showed norma distribution of B and T lymphocyes at 4 to 5 weeks of age but developed progressive generalized lymphadenopathy. IRF4-deficient mice exhibited a profound reduction in serum immunoglobulin concentrations and did not mount detectable antibody responses. T lymphocyte function was also impaired in vivo; these mice could not generate cytotoxic or antitumor responses. Thus, IRF4 is essential for the function and homeostasis of both mature B and mature T lymphocytes.
Persistent Identifierhttp://hdl.handle.net/10722/293053
ISSN
2023 Impact Factor: 3.6
2023 SCImago Journal Rankings: 1.558
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMittrücker, Hans Willi-
dc.contributor.authorMatsuyama, Toshifumi-
dc.contributor.authorGrossman, Alex-
dc.contributor.authorKündig, Thomas M.-
dc.contributor.authorPotter, Julia-
dc.contributor.authorShahinian, Arda-
dc.contributor.authorWakeham, Andrew-
dc.contributor.authorPatterson, Bruce-
dc.contributor.authorOhashi, Pamela S.-
dc.contributor.authorMak, Tak W.-
dc.date.accessioned2020-11-17T14:57:46Z-
dc.date.available2020-11-17T14:57:46Z-
dc.date.issued2017-
dc.identifier.citationJournal of Immunology, 2017, v. 199, n. 11, p. 3717-3720-
dc.identifier.issn0022-1767-
dc.identifier.urihttp://hdl.handle.net/10722/293053-
dc.description.abstractLymphocyte-specific interferon regulatory factor (LSIRF) (now called IRF4) is a transcription factor expressed only in lymphocytes. Mice deficient in IRF4 showed norma distribution of B and T lymphocyes at 4 to 5 weeks of age but developed progressive generalized lymphadenopathy. IRF4-deficient mice exhibited a profound reduction in serum immunoglobulin concentrations and did not mount detectable antibody responses. T lymphocyte function was also impaired in vivo; these mice could not generate cytotoxic or antitumor responses. Thus, IRF4 is essential for the function and homeostasis of both mature B and mature T lymphocytes.-
dc.languageeng-
dc.publisherThe American Association of Immunologists, Inc. The Journal's web site is located at https://www.jimmunol.org/-
dc.relation.ispartofJournal of Immunology-
dc.titlePillars Article: Requirement for the Transcription Factor LSIRF/IRF4 for Mature B and T Lymphocyte Function. Science. 1997. 275: 540–543-
dc.typeArticle-
dc.identifier.pmid29158347-
dc.identifier.scopuseid_2-s2.0-85034786212-
dc.identifier.volume199-
dc.identifier.issue11-
dc.identifier.spage3717-
dc.identifier.epage3720-
dc.identifier.eissn1550-6606-
dc.identifier.isiWOS:000415967800002-
dc.identifier.issnl0022-1767-

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