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Article: Theory of mind impairment and its clinical correlates in patients with schizophrenia, major depressive disorder and bipolar disorder

TitleTheory of mind impairment and its clinical correlates in patients with schizophrenia, major depressive disorder and bipolar disorder
Authors
KeywordsBipolar disorder
Network analysis
Schizophrenia
Theory of mind
Major depressive disorder
Cross-diagnostic
Issue Date2018
Citation
Schizophrenia Research, 2018, v. 197, p. 349-356 How to Cite?
Abstract© 2017 Elsevier B.V. Background: Although Theory of Mind (ToM) impairment has been observed in patients with a wide range of mental disorders, the similarity and uniqueness of these deficits across diagnostic groups has not been thoroughly investigated. Methods: We recruited 35 participants with schizophrenia (SCZ), 35 with bipolar disorder (BD), 35 with major depressive disorder (MDD), and 35 healthy controls in this study. All participants were matched in age, gender proportion and IQ estimates. The Yoni task, capturing both the cognitive and affective components of ToM at the first- and second-order level was administered. Repeated-measure ANOVA and MANOVA were conducted to compare the group differences in ToM performance. A network was then constructed with ToM performances, psychotic and depressive symptoms, and executive function as nodes exploring the clinical correlates of ToM. Results: Overall, ToM impairments were observed in all patient groups compared with healthy controls, with patients with SCZ performing worse than those with BD. In second-order conditions, patients with SCZ and MDD showed deficits in both cognitive and affective conditions, while patients with BD performed significantly poorer in cognitive conditions. Network analysis showed that second-order affective ToM performance was associated with psychotic and depressive symptoms as well as executive dysfunction, while second-order affective ToM performance and negative symptoms showed relatively high centrality in the network. Conclusions: Patients with SCZ, MDD and BD exhibited different types and severity of impairments in ToM sub-components. Impairment in higher-order affective ToM appears to be closely related to clinical symptoms in both psychotic and affective disorders.
Persistent Identifierhttp://hdl.handle.net/10722/293049
ISSN
2020 Impact Factor: 4.939
2020 SCImago Journal Rankings: 1.923
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWang, Yan yu-
dc.contributor.authorWang, Yi-
dc.contributor.authorZou, Ying min-
dc.contributor.authorNi, Ke-
dc.contributor.authorTian, Xue-
dc.contributor.authorSun, Hong wei-
dc.contributor.authorLui, Simon S.Y.-
dc.contributor.authorCheung, Eric F.C.-
dc.contributor.authorSuckling, John-
dc.contributor.authorChan, Raymond C.K.-
dc.date.accessioned2020-11-17T14:57:46Z-
dc.date.available2020-11-17T14:57:46Z-
dc.date.issued2018-
dc.identifier.citationSchizophrenia Research, 2018, v. 197, p. 349-356-
dc.identifier.issn0920-9964-
dc.identifier.urihttp://hdl.handle.net/10722/293049-
dc.description.abstract© 2017 Elsevier B.V. Background: Although Theory of Mind (ToM) impairment has been observed in patients with a wide range of mental disorders, the similarity and uniqueness of these deficits across diagnostic groups has not been thoroughly investigated. Methods: We recruited 35 participants with schizophrenia (SCZ), 35 with bipolar disorder (BD), 35 with major depressive disorder (MDD), and 35 healthy controls in this study. All participants were matched in age, gender proportion and IQ estimates. The Yoni task, capturing both the cognitive and affective components of ToM at the first- and second-order level was administered. Repeated-measure ANOVA and MANOVA were conducted to compare the group differences in ToM performance. A network was then constructed with ToM performances, psychotic and depressive symptoms, and executive function as nodes exploring the clinical correlates of ToM. Results: Overall, ToM impairments were observed in all patient groups compared with healthy controls, with patients with SCZ performing worse than those with BD. In second-order conditions, patients with SCZ and MDD showed deficits in both cognitive and affective conditions, while patients with BD performed significantly poorer in cognitive conditions. Network analysis showed that second-order affective ToM performance was associated with psychotic and depressive symptoms as well as executive dysfunction, while second-order affective ToM performance and negative symptoms showed relatively high centrality in the network. Conclusions: Patients with SCZ, MDD and BD exhibited different types and severity of impairments in ToM sub-components. Impairment in higher-order affective ToM appears to be closely related to clinical symptoms in both psychotic and affective disorders.-
dc.languageeng-
dc.relation.ispartofSchizophrenia Research-
dc.subjectBipolar disorder-
dc.subjectNetwork analysis-
dc.subjectSchizophrenia-
dc.subjectTheory of mind-
dc.subjectMajor depressive disorder-
dc.subjectCross-diagnostic-
dc.titleTheory of mind impairment and its clinical correlates in patients with schizophrenia, major depressive disorder and bipolar disorder-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.schres.2017.11.003-
dc.identifier.pmid29122405-
dc.identifier.scopuseid_2-s2.0-85032996040-
dc.identifier.hkuros320732-
dc.identifier.volume197-
dc.identifier.spage349-
dc.identifier.epage356-
dc.identifier.eissn1573-2509-
dc.identifier.isiWOS:000437786100052-
dc.identifier.issnl0920-9964-

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