File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Striatal dysfunction in patients with schizophrenia and their unaffected first-degree relatives

TitleStriatal dysfunction in patients with schizophrenia and their unaffected first-degree relatives
Authors
KeywordsNeural circuits
Dopamine
First-degree relative
Schizophrenia
Issue Date2018
Citation
Schizophrenia Research, 2018, v. 195, p. 215-221 How to Cite?
Abstract© 2017 Elsevier B.V. Despite empirical findings showing that patients with schizophrenia and their unaffected first-degree relatives have deficits in processing monetary incentives, it is unclear whether similar deficits could be demonstrated for affective incentives. Twenty-six patients with schizophrenia and 26 age and gender matched healthy controls; 23 unaffected first-degree relatives and 23 matched healthy controls were recruited to complete a Monetary Incentive Delay (MID) task and an Affective Incentive Delay (AID) task in a 3-Tesla MRI scanner. Hypoactivation in the dorsal striatum when anticipating monetary incentives were found in patients with schizophrenia and their unaffected first-degree relatives compared with healthy controls. Furthermore, patients with schizophrenia showed hyperactivation in the ventral striatum when receiving both monetary and affective incentives. These findings suggest that disorganized striatal function, regardless of incentive types, may be present in patients with schizophrenia and before the onset of illness in their first-degree unaffected relatives.
Persistent Identifierhttp://hdl.handle.net/10722/293041
ISSN
2023 Impact Factor: 3.6
2023 SCImago Journal Rankings: 1.374
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, Zhi-
dc.contributor.authorYan, Chao-
dc.contributor.authorLv, Qin yu-
dc.contributor.authorYi, Zheng hui-
dc.contributor.authorZhang, Jian ye-
dc.contributor.authorWang, Jin hong-
dc.contributor.authorLui, Simon S.Y.-
dc.contributor.authorXu, Yi feng-
dc.contributor.authorCheung, Eric F.C.-
dc.contributor.authorGur, Raquel E.-
dc.contributor.authorGur, Ruben C.-
dc.contributor.authorChan, Raymond C.K.-
dc.date.accessioned2020-11-17T14:57:45Z-
dc.date.available2020-11-17T14:57:45Z-
dc.date.issued2018-
dc.identifier.citationSchizophrenia Research, 2018, v. 195, p. 215-221-
dc.identifier.issn0920-9964-
dc.identifier.urihttp://hdl.handle.net/10722/293041-
dc.description.abstract© 2017 Elsevier B.V. Despite empirical findings showing that patients with schizophrenia and their unaffected first-degree relatives have deficits in processing monetary incentives, it is unclear whether similar deficits could be demonstrated for affective incentives. Twenty-six patients with schizophrenia and 26 age and gender matched healthy controls; 23 unaffected first-degree relatives and 23 matched healthy controls were recruited to complete a Monetary Incentive Delay (MID) task and an Affective Incentive Delay (AID) task in a 3-Tesla MRI scanner. Hypoactivation in the dorsal striatum when anticipating monetary incentives were found in patients with schizophrenia and their unaffected first-degree relatives compared with healthy controls. Furthermore, patients with schizophrenia showed hyperactivation in the ventral striatum when receiving both monetary and affective incentives. These findings suggest that disorganized striatal function, regardless of incentive types, may be present in patients with schizophrenia and before the onset of illness in their first-degree unaffected relatives.-
dc.languageeng-
dc.relation.ispartofSchizophrenia Research-
dc.subjectNeural circuits-
dc.subjectDopamine-
dc.subjectFirst-degree relative-
dc.subjectSchizophrenia-
dc.titleStriatal dysfunction in patients with schizophrenia and their unaffected first-degree relatives-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.schres.2017.08.043-
dc.identifier.pmid28867519-
dc.identifier.scopuseid_2-s2.0-85028514474-
dc.identifier.volume195-
dc.identifier.spage215-
dc.identifier.epage221-
dc.identifier.eissn1573-2509-
dc.identifier.isiWOS:000432466700031-
dc.identifier.issnl0920-9964-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats