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- Publisher Website: 10.1158/2159-8290.CD-16-0789
- Scopus: eid_2-s2.0-85012022683
- PMID: 27587465
- WOS: WOS:000383356400018
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Article: Activating TCR signaling to thwart T-all
Title | Activating TCR signaling to thwart T-all |
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Authors | |
Issue Date | 2016 |
Citation | Cancer Discovery, 2016, v. 6, n. 9, p. 946-948 How to Cite? |
Abstract | © 2016 American Association for Cancer Research. Thymic negative selection is a process that aims to eliminate autoreactive T cells by inducing the apoptosis of thymocytes expressing a T-cell receptor (TCR) with high affinity for self-MHC. In this issue, Trinquand and colleagues demonstrate that TCR engagement or anti-CD3 stimulation of TCR-expressing T acute lymphoblastic leukemia cells results in their apoptosis. This cell death is reminiscent of thymic negative selection and has the potential for therapeutic exploitation. |
Persistent Identifier | http://hdl.handle.net/10722/292998 |
ISSN | 2023 Impact Factor: 29.7 2023 SCImago Journal Rankings: 7.533 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Lemonnier, François | - |
dc.contributor.author | Mak, Tak W. | - |
dc.date.accessioned | 2020-11-17T14:57:39Z | - |
dc.date.available | 2020-11-17T14:57:39Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Cancer Discovery, 2016, v. 6, n. 9, p. 946-948 | - |
dc.identifier.issn | 2159-8274 | - |
dc.identifier.uri | http://hdl.handle.net/10722/292998 | - |
dc.description.abstract | © 2016 American Association for Cancer Research. Thymic negative selection is a process that aims to eliminate autoreactive T cells by inducing the apoptosis of thymocytes expressing a T-cell receptor (TCR) with high affinity for self-MHC. In this issue, Trinquand and colleagues demonstrate that TCR engagement or anti-CD3 stimulation of TCR-expressing T acute lymphoblastic leukemia cells results in their apoptosis. This cell death is reminiscent of thymic negative selection and has the potential for therapeutic exploitation. | - |
dc.language | eng | - |
dc.relation.ispartof | Cancer Discovery | - |
dc.title | Activating TCR signaling to thwart T-all | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1158/2159-8290.CD-16-0789 | - |
dc.identifier.pmid | 27587465 | - |
dc.identifier.scopus | eid_2-s2.0-85012022683 | - |
dc.identifier.volume | 6 | - |
dc.identifier.issue | 9 | - |
dc.identifier.spage | 946 | - |
dc.identifier.epage | 948 | - |
dc.identifier.eissn | 2159-8290 | - |
dc.identifier.isi | WOS:000383356400018 | - |
dc.identifier.issnl | 2159-8274 | - |