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- Publisher Website: 10.1016/j.jaut.2016.12.010
- Scopus: eid_2-s2.0-85009446385
- PMID: 28089248
- WOS: WOS:000396948300010
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Article: Triggering receptor expressed on myeloid cells-1 (TREM-1) deficiency augments BAFF production to promote lupus progression
Title | Triggering receptor expressed on myeloid cells-1 (TREM-1) deficiency augments BAFF production to promote lupus progression |
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Authors | |
Keywords | B cell-activating factor lpr mice Systemic lupus erythematosus Triggering receptor expressed on myeloid cells-1 |
Issue Date | 2017 |
Citation | Journal of Autoimmunity, 2017, v. 78, p. 92-100 How to Cite? |
Abstract | © 2017 Elsevier Ltd Sensing of nucleic acids by pattern recognition receptors is the key for the initiation and development of systemic lupus erythematosus (SLE). Triggering receptor expressed on myeloid cells-1 (TREM-1) is a novel innate immune receptor, which can amplify Toll-like receptor (TLR)-induced inflammatory responses. Although patients with lupus exhibit increased serum levels of soluble TREM-1 (sTREM-1), the role of TREM-1 in SLE remains unknown. In current study, we found serum sTREM-1 levels were significantly increased in lupus patients and positively correlated with disease activity. Additionally, diseased B6.lpr mice had elevated TREM-1 in the serum, spleen, and lymph nodes. To investigate the role of TREM-1 in lupus, we established Trem-1−/−.lpr mice. Trem-1−/−.lpr mice exhibited lower survival rates and more severe lupus symptoms, including elevated proteinuria, serum anti-dsDNA antibody levels, renal immune complex depositions and lymphocyte subpopulation expansions in both the spleen and lymph nodes. Besides, Trem-1−/−.lpr mice expressed higher serum B cell-activating factor (BAFF) levels and lymph node dendritic cells (DCs) were the major source of increased BAFF. Activation of membrane-bound TREM-1 could suppress TLR9-induced BAFF expression in bone marrow-derived DCs of B6.lpr mice. Moreover, levels of sTREM-1, which could act as an antagonist of membrane-bound TREM-1, were positively correlated with levels of BAFF in the sera of lupus patients. Our findings suggest a novel modulatory role of TREM-1 in the pathogenesis of SLE. sTREM-1 production is a useful diagnostic marker and a molecular target for combination therapy of lupus. |
Persistent Identifier | http://hdl.handle.net/10722/292992 |
ISSN | 2023 Impact Factor: 7.9 2023 SCImago Journal Rankings: 2.558 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Liu, Chi Jui | - |
dc.contributor.author | Tsai, Chang Youh | - |
dc.contributor.author | Chiang, Ssu Hsuan | - |
dc.contributor.author | Tang, Shye Jye | - |
dc.contributor.author | Chen, Nien Jung | - |
dc.contributor.author | Mak, Tak Wah | - |
dc.contributor.author | Sun, Guang Huan | - |
dc.contributor.author | Sun, Kuang Hui | - |
dc.date.accessioned | 2020-11-17T14:57:39Z | - |
dc.date.available | 2020-11-17T14:57:39Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Journal of Autoimmunity, 2017, v. 78, p. 92-100 | - |
dc.identifier.issn | 0896-8411 | - |
dc.identifier.uri | http://hdl.handle.net/10722/292992 | - |
dc.description.abstract | © 2017 Elsevier Ltd Sensing of nucleic acids by pattern recognition receptors is the key for the initiation and development of systemic lupus erythematosus (SLE). Triggering receptor expressed on myeloid cells-1 (TREM-1) is a novel innate immune receptor, which can amplify Toll-like receptor (TLR)-induced inflammatory responses. Although patients with lupus exhibit increased serum levels of soluble TREM-1 (sTREM-1), the role of TREM-1 in SLE remains unknown. In current study, we found serum sTREM-1 levels were significantly increased in lupus patients and positively correlated with disease activity. Additionally, diseased B6.lpr mice had elevated TREM-1 in the serum, spleen, and lymph nodes. To investigate the role of TREM-1 in lupus, we established Trem-1−/−.lpr mice. Trem-1−/−.lpr mice exhibited lower survival rates and more severe lupus symptoms, including elevated proteinuria, serum anti-dsDNA antibody levels, renal immune complex depositions and lymphocyte subpopulation expansions in both the spleen and lymph nodes. Besides, Trem-1−/−.lpr mice expressed higher serum B cell-activating factor (BAFF) levels and lymph node dendritic cells (DCs) were the major source of increased BAFF. Activation of membrane-bound TREM-1 could suppress TLR9-induced BAFF expression in bone marrow-derived DCs of B6.lpr mice. Moreover, levels of sTREM-1, which could act as an antagonist of membrane-bound TREM-1, were positively correlated with levels of BAFF in the sera of lupus patients. Our findings suggest a novel modulatory role of TREM-1 in the pathogenesis of SLE. sTREM-1 production is a useful diagnostic marker and a molecular target for combination therapy of lupus. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of Autoimmunity | - |
dc.subject | B cell-activating factor | - |
dc.subject | lpr mice | - |
dc.subject | Systemic lupus erythematosus | - |
dc.subject | Triggering receptor expressed on myeloid cells-1 | - |
dc.title | Triggering receptor expressed on myeloid cells-1 (TREM-1) deficiency augments BAFF production to promote lupus progression | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.jaut.2016.12.010 | - |
dc.identifier.pmid | 28089248 | - |
dc.identifier.scopus | eid_2-s2.0-85009446385 | - |
dc.identifier.volume | 78 | - |
dc.identifier.spage | 92 | - |
dc.identifier.epage | 100 | - |
dc.identifier.eissn | 1095-9157 | - |
dc.identifier.isi | WOS:000396948300010 | - |
dc.identifier.issnl | 0896-8411 | - |