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Article: Plasma miR-124-3p and miR-16 concentrations as prognostic markers in acute stroke

TitlePlasma miR-124-3p and miR-16 concentrations as prognostic markers in acute stroke
Authors
KeywordsMicroRNA
Stroke
Plasma
Prognosis
Issue Date2016
Citation
Clinical Biochemistry, 2016, v. 49, n. 9, p. 663-668 How to Cite?
Abstract© 2016 The Canadian Society of Clinical Chemists. Objectives: This study aimed to investigate plasma concentrations of miR-124-3p and miR-16 as prognostic markers in emergency department patients with acute stroke. Design and methods: Plasma concentrations of miR-124-3p and miR-16 of 84 stroke patients (presenting to the emergency department within 24 h from onset of symptoms) were determined by RT-qPCR. The primary outcome measure was 3-month mortality and the secondary outcome measure was post-stroke modified Rankin Score (mRS). Results: Twelve patients (14.3%) died within 3 months of hospital admission and forty-one (48.8%) patients as achieved a 3-month mRS > 2. Median plasma miR-124-3p concentrations were elevated in patients who died compared to patients who survived (p = 0.0052), and its levels were found to be higher in patients with a 3-month mRS > 2 compared with patients with mRS ≤ 2 (p = 0.0312). Higher plasma miR-16 concentrations were observed in patients who survived than in patients who died (p = 0.0394), while its concentrations were lower in patients achieving mRS > 2 than in patients with mRS ≤ 2 (p = 0.0124). For a subgroup of cases presenting to the emergency department within 6 h from time of symptom onset (n = 36), plasma miR-124-3p concentrations predicted 3-month mortality with an area under the ROC curve of 0.87 (95%CI: 0.72-0.96). Conclusions: Plasma miR-124-3p and miR-16 are molecular markers which could be useful for the early prediction of mortality and mRS.
Persistent Identifierhttp://hdl.handle.net/10722/292944
ISSN
2023 Impact Factor: 2.5
2023 SCImago Journal Rankings: 0.703
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorRainer, Timothy Hudson-
dc.contributor.authorLeung, Ling Yan-
dc.contributor.authorChan, Cangel Pui Yee-
dc.contributor.authorLeung, Yuk Ki-
dc.contributor.authorAbrigo, Jill Morales-
dc.contributor.authorWang, Defeng-
dc.contributor.authorGraham, Colin A.-
dc.date.accessioned2020-11-17T14:57:33Z-
dc.date.available2020-11-17T14:57:33Z-
dc.date.issued2016-
dc.identifier.citationClinical Biochemistry, 2016, v. 49, n. 9, p. 663-668-
dc.identifier.issn0009-9120-
dc.identifier.urihttp://hdl.handle.net/10722/292944-
dc.description.abstract© 2016 The Canadian Society of Clinical Chemists. Objectives: This study aimed to investigate plasma concentrations of miR-124-3p and miR-16 as prognostic markers in emergency department patients with acute stroke. Design and methods: Plasma concentrations of miR-124-3p and miR-16 of 84 stroke patients (presenting to the emergency department within 24 h from onset of symptoms) were determined by RT-qPCR. The primary outcome measure was 3-month mortality and the secondary outcome measure was post-stroke modified Rankin Score (mRS). Results: Twelve patients (14.3%) died within 3 months of hospital admission and forty-one (48.8%) patients as achieved a 3-month mRS > 2. Median plasma miR-124-3p concentrations were elevated in patients who died compared to patients who survived (p = 0.0052), and its levels were found to be higher in patients with a 3-month mRS > 2 compared with patients with mRS ≤ 2 (p = 0.0312). Higher plasma miR-16 concentrations were observed in patients who survived than in patients who died (p = 0.0394), while its concentrations were lower in patients achieving mRS > 2 than in patients with mRS ≤ 2 (p = 0.0124). For a subgroup of cases presenting to the emergency department within 6 h from time of symptom onset (n = 36), plasma miR-124-3p concentrations predicted 3-month mortality with an area under the ROC curve of 0.87 (95%CI: 0.72-0.96). Conclusions: Plasma miR-124-3p and miR-16 are molecular markers which could be useful for the early prediction of mortality and mRS.-
dc.languageeng-
dc.relation.ispartofClinical Biochemistry-
dc.subjectMicroRNA-
dc.subjectStroke-
dc.subjectPlasma-
dc.subjectPrognosis-
dc.titlePlasma miR-124-3p and miR-16 concentrations as prognostic markers in acute stroke-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.clinbiochem.2016.02.016-
dc.identifier.pmid26968104-
dc.identifier.scopuseid_2-s2.0-84970027687-
dc.identifier.volume49-
dc.identifier.issue9-
dc.identifier.spage663-
dc.identifier.epage668-
dc.identifier.eissn1873-2933-
dc.identifier.isiWOS:000377030600005-
dc.identifier.issnl0009-9120-

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