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- Publisher Website: 10.1038/nri3834
- Scopus: eid_2-s2.0-84929875491
- PMID: 26008591
- WOS: WOS:000355205600008
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Article: Regulation of tumour necrosis factor signalling: Live or let die
| Title | Regulation of tumour necrosis factor signalling: Live or let die |
|---|---|
| Authors | |
| Issue Date | 2015 |
| Citation | Nature Reviews Immunology, 2015, v. 15, n. 6, p. 362-374 How to Cite? |
| Abstract | © 2015 MacmillanPublishers Limited. Tumour necrosis factor (TNF) is a pro-inflammatory cytokine that has important roles in mammalian immunity and cellular homeostasis. Deregulation of TNF receptor (TNFR) signalling is associated with many inflammatory disorders, including various types of arthritis and inflammatory bowel disease, and targeting TNF has been an effective therapeutic strategy in these diseases. This Review focuses on the recent advances that have been made in understanding TNFR signalling and the consequences of its deregulation for cellular survival, apoptosis and regulated necrosis. We discuss how TNF-induced survival signals are distinguished from those that lead to cell death. Finally, we provide a brief overview of the role of TNF in inflammatory and autoimmune diseases, and we discuss up-to-date and future treatment strategies for these disorders. |
| Persistent Identifier | http://hdl.handle.net/10722/292886 |
| ISSN | 2023 Impact Factor: 67.7 2023 SCImago Journal Rankings: 16.009 |
| ISI Accession Number ID |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Brenner, Dirk | - |
| dc.contributor.author | Blaser, Heiko | - |
| dc.contributor.author | Mak, Tak W. | - |
| dc.date.accessioned | 2020-11-17T14:57:25Z | - |
| dc.date.available | 2020-11-17T14:57:25Z | - |
| dc.date.issued | 2015 | - |
| dc.identifier.citation | Nature Reviews Immunology, 2015, v. 15, n. 6, p. 362-374 | - |
| dc.identifier.issn | 1474-1733 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/292886 | - |
| dc.description.abstract | © 2015 MacmillanPublishers Limited. Tumour necrosis factor (TNF) is a pro-inflammatory cytokine that has important roles in mammalian immunity and cellular homeostasis. Deregulation of TNF receptor (TNFR) signalling is associated with many inflammatory disorders, including various types of arthritis and inflammatory bowel disease, and targeting TNF has been an effective therapeutic strategy in these diseases. This Review focuses on the recent advances that have been made in understanding TNFR signalling and the consequences of its deregulation for cellular survival, apoptosis and regulated necrosis. We discuss how TNF-induced survival signals are distinguished from those that lead to cell death. Finally, we provide a brief overview of the role of TNF in inflammatory and autoimmune diseases, and we discuss up-to-date and future treatment strategies for these disorders. | - |
| dc.language | eng | - |
| dc.relation.ispartof | Nature Reviews Immunology | - |
| dc.title | Regulation of tumour necrosis factor signalling: Live or let die | - |
| dc.type | Article | - |
| dc.description.nature | link_to_subscribed_fulltext | - |
| dc.identifier.doi | 10.1038/nri3834 | - |
| dc.identifier.pmid | 26008591 | - |
| dc.identifier.scopus | eid_2-s2.0-84929875491 | - |
| dc.identifier.volume | 15 | - |
| dc.identifier.issue | 6 | - |
| dc.identifier.spage | 362 | - |
| dc.identifier.epage | 374 | - |
| dc.identifier.eissn | 1474-1741 | - |
| dc.identifier.isi | WOS:000355205600008 | - |
| dc.identifier.issnl | 1474-1733 | - |