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Article: Comparison of miR-124-3p and miR-16 for early diagnosis of hemorrhagic and ischemic stroke

TitleComparison of miR-124-3p and miR-16 for early diagnosis of hemorrhagic and ischemic stroke
Authors
KeywordsHemorrhagic stroke
Plasma
MicroRNA
Diagnosis
Ischemic stroke
Issue Date2014
Citation
Clinica Chimica Acta, 2014, v. 433, p. 139-144 How to Cite?
AbstractBackground: The present study aimed to investigate and compare plasma concentrations of miR-124-3p and miR-16 as diagnostic markers in acute stroke. Methods: miR-124-3p and miR-16 concentrations in 93 stroke patients were analyzed using real-time polymerase chain reaction. The primary outcome was the differentiation of hemorrhagic and ischemic stroke. Results: Of 93 patients, 74 (79.6%) were diagnosed as ischemic stroke (IS) and 19 (20.4%) were diagnosed as hemorrhagic stroke (HS). Median plasma 124-3p concentrations taken within 24h of symptom onset were higher in HS patients than that in IS patients (3.8×105 vs 2.0×105 copies/ml plasma, p=0.0109), while median miR-16 concentration in IS patients were higher than that in HS patients (1.6×109 vs 1.3×109 copies/ml plasma, p=0.0399). The odds ratio (OR) for discriminating HS and IS with miR-124-3p and miR-16 was 5.37 and 9.75 respectively. Conclusion: Both miR-124-3p and miR-16 are diagnostic markers to discriminate HS and IS. © 2014.
Persistent Identifierhttp://hdl.handle.net/10722/292816
ISSN
2023 Impact Factor: 3.2
2023 SCImago Journal Rankings: 1.016
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLeung, Ling Yan-
dc.contributor.authorChan, Cangel Pui Yee-
dc.contributor.authorLeung, Yuk Ki-
dc.contributor.authorJiang, Hui Lin-
dc.contributor.authorAbrigo, Jill Morales-
dc.contributor.authorWang, De Feng-
dc.contributor.authorChung, Joseph Shun Hang-
dc.contributor.authorRainer, Timothy Hudson-
dc.contributor.authorGraham, Colin Alexander-
dc.date.accessioned2020-11-17T14:57:16Z-
dc.date.available2020-11-17T14:57:16Z-
dc.date.issued2014-
dc.identifier.citationClinica Chimica Acta, 2014, v. 433, p. 139-144-
dc.identifier.issn0009-8981-
dc.identifier.urihttp://hdl.handle.net/10722/292816-
dc.description.abstractBackground: The present study aimed to investigate and compare plasma concentrations of miR-124-3p and miR-16 as diagnostic markers in acute stroke. Methods: miR-124-3p and miR-16 concentrations in 93 stroke patients were analyzed using real-time polymerase chain reaction. The primary outcome was the differentiation of hemorrhagic and ischemic stroke. Results: Of 93 patients, 74 (79.6%) were diagnosed as ischemic stroke (IS) and 19 (20.4%) were diagnosed as hemorrhagic stroke (HS). Median plasma 124-3p concentrations taken within 24h of symptom onset were higher in HS patients than that in IS patients (3.8×105 vs 2.0×105 copies/ml plasma, p=0.0109), while median miR-16 concentration in IS patients were higher than that in HS patients (1.6×109 vs 1.3×109 copies/ml plasma, p=0.0399). The odds ratio (OR) for discriminating HS and IS with miR-124-3p and miR-16 was 5.37 and 9.75 respectively. Conclusion: Both miR-124-3p and miR-16 are diagnostic markers to discriminate HS and IS. © 2014.-
dc.languageeng-
dc.relation.ispartofClinica Chimica Acta-
dc.subjectHemorrhagic stroke-
dc.subjectPlasma-
dc.subjectMicroRNA-
dc.subjectDiagnosis-
dc.subjectIschemic stroke-
dc.titleComparison of miR-124-3p and miR-16 for early diagnosis of hemorrhagic and ischemic stroke-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.cca.2014.03.007-
dc.identifier.pmid24650689-
dc.identifier.scopuseid_2-s2.0-84897412976-
dc.identifier.volume433-
dc.identifier.spage139-
dc.identifier.epage144-
dc.identifier.eissn1873-3492-
dc.identifier.isiWOS:000337992200024-
dc.identifier.issnl0009-8981-

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