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- Publisher Website: 10.1016/j.molimm.2013.04.008
- Scopus: eid_2-s2.0-84877893902
- PMID: 23685259
- WOS: WOS:000321882800005
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Article: Promoting immunity during chronic infection-The therapeutic potential of common gamma-chain cytokines
Title | Promoting immunity during chronic infection-The therapeutic potential of common gamma-chain cytokines |
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Authors | |
Keywords | HIV Cytokines Infection CD8 T cell + Therapy Common gamma-chain |
Issue Date | 2013 |
Citation | Molecular Immunology, 2013, v. 56, n. 1-2, p. 38-47 How to Cite? |
Abstract | The continued global burden wrought by chronic infectious disease is unrelenting. Current therapies have curbed the severity of disease for patients, but Human Immunodeficiency Virus (HIV) and Hepatitis B (HBV) infection remain incurable and Mycobacterium tuberculosis (MTB) is rapidly becoming resistant to our existing antibiotics. Much attention has been given to enhancing T cell immunity through the use of certain common gamma-chain cytokines, which have proven to be essential and necessary for T cell survival and function. This article reviews the pre-clinical and clinical literature surrounding IL-2, IL-7, IL-15 and IL-21 and we comment on the potential therapeutic promise of these cytokines as adjuvant treatments for chronic infectious diseases. © 2013 Elsevier Ltd. |
Persistent Identifier | http://hdl.handle.net/10722/292749 |
ISSN | 2023 Impact Factor: 3.2 2023 SCImago Journal Rankings: 0.892 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Toe, Jesse G. | - |
dc.contributor.author | Pellegrini, Marc | - |
dc.contributor.author | Mak, Tak Wah | - |
dc.date.accessioned | 2020-11-17T14:57:08Z | - |
dc.date.available | 2020-11-17T14:57:08Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Molecular Immunology, 2013, v. 56, n. 1-2, p. 38-47 | - |
dc.identifier.issn | 0161-5890 | - |
dc.identifier.uri | http://hdl.handle.net/10722/292749 | - |
dc.description.abstract | The continued global burden wrought by chronic infectious disease is unrelenting. Current therapies have curbed the severity of disease for patients, but Human Immunodeficiency Virus (HIV) and Hepatitis B (HBV) infection remain incurable and Mycobacterium tuberculosis (MTB) is rapidly becoming resistant to our existing antibiotics. Much attention has been given to enhancing T cell immunity through the use of certain common gamma-chain cytokines, which have proven to be essential and necessary for T cell survival and function. This article reviews the pre-clinical and clinical literature surrounding IL-2, IL-7, IL-15 and IL-21 and we comment on the potential therapeutic promise of these cytokines as adjuvant treatments for chronic infectious diseases. © 2013 Elsevier Ltd. | - |
dc.language | eng | - |
dc.relation.ispartof | Molecular Immunology | - |
dc.subject | HIV | - |
dc.subject | Cytokines | - |
dc.subject | Infection | - |
dc.subject | CD8 T cell + | - |
dc.subject | Therapy | - |
dc.subject | Common gamma-chain | - |
dc.title | Promoting immunity during chronic infection-The therapeutic potential of common gamma-chain cytokines | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.molimm.2013.04.008 | - |
dc.identifier.pmid | 23685259 | - |
dc.identifier.scopus | eid_2-s2.0-84877893902 | - |
dc.identifier.volume | 56 | - |
dc.identifier.issue | 1-2 | - |
dc.identifier.spage | 38 | - |
dc.identifier.epage | 47 | - |
dc.identifier.eissn | 1872-9142 | - |
dc.identifier.isi | WOS:000321882800005 | - |
dc.identifier.issnl | 0161-5890 | - |