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Article: microRNA-34a regulates neurite outgrowth, spinal morphology, and function

TitlemicroRNA-34a regulates neurite outgrowth, spinal morphology, and function
Authors
KeywordsCell death
Neuronal differentiation
Synaptogenesis
Hippocampus
Issue Date2011
Citation
Proceedings of the National Academy of Sciences of the United States of America, 2011, v. 108, n. 52, p. 21099-21104 How to Cite?
AbstractThe p53 family member TAp73 is a transcription factor that plays a key role in many biological processes, including neuronal development. In particular, wehave shown that p73 drives the expression of miR-34a, but not miR-34b and c, in mouse cortical neurons. miR-34a in turn modulates the expression of synaptic targets including synaptotagmin-1 and syntaxin-1A. Here we show that this axis is retained in mouse ES cells committed to differentiate toward a neurological phenotype. Moreover, overexpression of miR-34a alters hippocampal spinal morphology, and results in electrophysiological changes consistent with a reduction in spinal function. Therefore, the TAp73/miR-34a axis has functional relevance in primary neurons. These data reinforce a role for miR-34a in neuronal development.
Persistent Identifierhttp://hdl.handle.net/10722/292683
ISSN
2023 Impact Factor: 9.4
2023 SCImago Journal Rankings: 3.737
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorAgostini, Massimiliano-
dc.contributor.authorTucci, Paola-
dc.contributor.authorSteinert, Joern R.-
dc.contributor.authorShalom-Feuerstein, Ruby-
dc.contributor.authorRouleau, Matthieu-
dc.contributor.authorAberdam, Daniel-
dc.contributor.authorForsythe, Ian D.-
dc.contributor.authorYoung, Kenneth W.-
dc.contributor.authorVentura, Andrea-
dc.contributor.authorConcepcion, Carla P.-
dc.contributor.authorHan, Yoon Chi-
dc.contributor.authorCandi, Eleonora-
dc.contributor.authorKnight, Richard A.-
dc.contributor.authorMak, Tak W.-
dc.contributor.authorMelino, Gerry-
dc.date.accessioned2020-11-17T14:57:00Z-
dc.date.available2020-11-17T14:57:00Z-
dc.date.issued2011-
dc.identifier.citationProceedings of the National Academy of Sciences of the United States of America, 2011, v. 108, n. 52, p. 21099-21104-
dc.identifier.issn0027-8424-
dc.identifier.urihttp://hdl.handle.net/10722/292683-
dc.description.abstractThe p53 family member TAp73 is a transcription factor that plays a key role in many biological processes, including neuronal development. In particular, wehave shown that p73 drives the expression of miR-34a, but not miR-34b and c, in mouse cortical neurons. miR-34a in turn modulates the expression of synaptic targets including synaptotagmin-1 and syntaxin-1A. Here we show that this axis is retained in mouse ES cells committed to differentiate toward a neurological phenotype. Moreover, overexpression of miR-34a alters hippocampal spinal morphology, and results in electrophysiological changes consistent with a reduction in spinal function. Therefore, the TAp73/miR-34a axis has functional relevance in primary neurons. These data reinforce a role for miR-34a in neuronal development.-
dc.languageeng-
dc.relation.ispartofProceedings of the National Academy of Sciences of the United States of America-
dc.subjectCell death-
dc.subjectNeuronal differentiation-
dc.subjectSynaptogenesis-
dc.subjectHippocampus-
dc.titlemicroRNA-34a regulates neurite outgrowth, spinal morphology, and function-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1073/pnas.1112063108-
dc.identifier.pmid22160706-
dc.identifier.pmcidPMC3248521-
dc.identifier.scopuseid_2-s2.0-84855495456-
dc.identifier.volume108-
dc.identifier.issue52-
dc.identifier.spage21099-
dc.identifier.epage21104-
dc.identifier.eissn1091-6490-
dc.identifier.isiWOS:000298479900049-
dc.identifier.issnl0027-8424-

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