File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit

TitleAcetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit
Authors
Issue Date2011
Citation
Science, 2011, v. 334, n. 6052, p. 98-101 How to Cite?
AbstractNeural circuits regulate cytokine production to prevent potentially damaging inflammation. A prototypical vagus nerve circuit, the inflammatory reflex, inhibits tumor necrosis factor-α production in spleen by a mechanism requiring acetylcholine signaling through the α7 nicotinic acetylcholine receptor expressed on cytokine-producing macrophages. Nerve fibers in spleen lack the enzymatic machinery necessary for acetylcholine production; therefore, how does this neural circuit terminate in cholinergic signaling? We identified an acetylcholine-producing, memory phenotype T cell population in mice that is integral to the inflammatory reflex. These acetylcholine-producing T cells are required for inhibition of cytokine production by vagus nerve stimulation. Thus, action potentials originating in the vagus nerve regulate T cells, which in turn produce the neurotransmitter, acetylcholine, required to control innate immune responses.
Persistent Identifierhttp://hdl.handle.net/10722/292661
ISSN
2023 Impact Factor: 44.7
2023 SCImago Journal Rankings: 11.902
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorRosas-Ballina, Mauricio-
dc.contributor.authorOlofsson, Peder S.-
dc.contributor.authorOchani, Mahendar-
dc.contributor.authorValdés-Ferrer, Sergio I.-
dc.contributor.authorLevine, Yaakov A.-
dc.contributor.authorReardon, Colin-
dc.contributor.authorTusche, Michael W.-
dc.contributor.authorPavlov, Valentin A.-
dc.contributor.authorAndersson, Ulf-
dc.contributor.authorChavan, Sangeeta-
dc.contributor.authorMak, Tak W.-
dc.contributor.authorTracey, Kevin J.-
dc.date.accessioned2020-11-17T14:56:57Z-
dc.date.available2020-11-17T14:56:57Z-
dc.date.issued2011-
dc.identifier.citationScience, 2011, v. 334, n. 6052, p. 98-101-
dc.identifier.issn0036-8075-
dc.identifier.urihttp://hdl.handle.net/10722/292661-
dc.description.abstractNeural circuits regulate cytokine production to prevent potentially damaging inflammation. A prototypical vagus nerve circuit, the inflammatory reflex, inhibits tumor necrosis factor-α production in spleen by a mechanism requiring acetylcholine signaling through the α7 nicotinic acetylcholine receptor expressed on cytokine-producing macrophages. Nerve fibers in spleen lack the enzymatic machinery necessary for acetylcholine production; therefore, how does this neural circuit terminate in cholinergic signaling? We identified an acetylcholine-producing, memory phenotype T cell population in mice that is integral to the inflammatory reflex. These acetylcholine-producing T cells are required for inhibition of cytokine production by vagus nerve stimulation. Thus, action potentials originating in the vagus nerve regulate T cells, which in turn produce the neurotransmitter, acetylcholine, required to control innate immune responses.-
dc.languageeng-
dc.relation.ispartofScience-
dc.titleAcetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1126/science.1209985-
dc.identifier.pmid21921156-
dc.identifier.pmcidPMC4548937-
dc.identifier.scopuseid_2-s2.0-80053593864-
dc.identifier.volume334-
dc.identifier.issue6052-
dc.identifier.spage98-
dc.identifier.epage101-
dc.identifier.eissn1095-9203-
dc.identifier.isiWOS:000295580300048-
dc.identifier.f100013353011-
dc.identifier.issnl0036-8075-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats