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Article: Topographic patterns of small subcortical infarcts associated with MCA stenosis: a diffusion-weighted MRI study

TitleTopographic patterns of small subcortical infarcts associated with MCA stenosis: a diffusion-weighted MRI study
Authors
KeywordsDiffusion-weighted imaging
MCA stenosis
Small subcortical infarcts
Embolism
Stroke
Issue Date2006
Citation
Journal of Neuroimaging, 2006, v. 16, n. 3, p. 266-271 How to Cite?
AbstractBackground and Purpose. Small subcortical infarcts (SSI, maximum lesion diameter ≤2.0 cm) are usually considered as infarcts caused by small vessel disease. However, SSI can also be associated with large artery occlusive disease such as middle cerebral artery (MCA) stenosis. We performed a prospective study to investigate the relationship between MCA stenosis and SSI distribution and further to investigate the mechanism of SSI caused by MCA stenosis. Methods. Magnetic resonance angiography (MRA) and diffusion-weighed MRI (DWI) of consecutive acute ischemic stroke patients with recent SSI were studied. The distribution of acute infarcts on DWI was categorized as cortical infarct (CI), border zone infarct (BI), or perforating artery infarct (PAI). Results. Totally, 93 cases were recruited, among which 12 had single SSI with MCA stenosis (group 1) and 26 patients had multiple SSI with MCA stenosis (group 2), while 55 patients without MCA stenosis had single SSI (group 3). For patients with single SSI and MCA stenosis, 6 had BI and 6 had PAI; for patients with multiple SSI and MCA stenosis, 25 had BI, 4 had PAI and 9 had CI (compared with group1: P =.001); for patients with single SSI but without MCA stenosis, 20 had BI and 35 had PAI (compared with group1: P =.58). Conclusion. Multiple acute infarcts along the border zone are the commonest pattern in small infarcts with MCA stenosis, especially among those with multiple acute infarcts. Our data suggest that hemodynamic compromise and artery-to-artery embolism may be both important factors for infarcts in patients with MCA stenosis. © 2006 by the American Society of Neuroimaging.
Persistent Identifierhttp://hdl.handle.net/10722/292584
ISSN
2023 Impact Factor: 2.3
2023 SCImago Journal Rankings: 0.794
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWang, Xin-
dc.contributor.authorLam, Wynnie W.M.-
dc.contributor.authorFan, Yu Hua-
dc.contributor.authorGraham, Colin A.-
dc.contributor.authorRainer, Timothy H.-
dc.contributor.authorWong, Ka Sing-
dc.date.accessioned2020-11-17T14:56:47Z-
dc.date.available2020-11-17T14:56:47Z-
dc.date.issued2006-
dc.identifier.citationJournal of Neuroimaging, 2006, v. 16, n. 3, p. 266-271-
dc.identifier.issn1051-2284-
dc.identifier.urihttp://hdl.handle.net/10722/292584-
dc.description.abstractBackground and Purpose. Small subcortical infarcts (SSI, maximum lesion diameter ≤2.0 cm) are usually considered as infarcts caused by small vessel disease. However, SSI can also be associated with large artery occlusive disease such as middle cerebral artery (MCA) stenosis. We performed a prospective study to investigate the relationship between MCA stenosis and SSI distribution and further to investigate the mechanism of SSI caused by MCA stenosis. Methods. Magnetic resonance angiography (MRA) and diffusion-weighed MRI (DWI) of consecutive acute ischemic stroke patients with recent SSI were studied. The distribution of acute infarcts on DWI was categorized as cortical infarct (CI), border zone infarct (BI), or perforating artery infarct (PAI). Results. Totally, 93 cases were recruited, among which 12 had single SSI with MCA stenosis (group 1) and 26 patients had multiple SSI with MCA stenosis (group 2), while 55 patients without MCA stenosis had single SSI (group 3). For patients with single SSI and MCA stenosis, 6 had BI and 6 had PAI; for patients with multiple SSI and MCA stenosis, 25 had BI, 4 had PAI and 9 had CI (compared with group1: P =.001); for patients with single SSI but without MCA stenosis, 20 had BI and 35 had PAI (compared with group1: P =.58). Conclusion. Multiple acute infarcts along the border zone are the commonest pattern in small infarcts with MCA stenosis, especially among those with multiple acute infarcts. Our data suggest that hemodynamic compromise and artery-to-artery embolism may be both important factors for infarcts in patients with MCA stenosis. © 2006 by the American Society of Neuroimaging.-
dc.languageeng-
dc.relation.ispartofJournal of Neuroimaging-
dc.subjectDiffusion-weighted imaging-
dc.subjectMCA stenosis-
dc.subjectSmall subcortical infarcts-
dc.subjectEmbolism-
dc.subjectStroke-
dc.titleTopographic patterns of small subcortical infarcts associated with MCA stenosis: a diffusion-weighted MRI study-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1552-6569.2006.00027.x-
dc.identifier.pmid16808829-
dc.identifier.scopuseid_2-s2.0-33748472468-
dc.identifier.volume16-
dc.identifier.issue3-
dc.identifier.spage266-
dc.identifier.epage271-
dc.identifier.eissn1552-6569-
dc.identifier.isiWOS:000238619700011-
dc.identifier.issnl1051-2284-

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