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Article: Adhesive mechanisms governing interferon-producing cell recruitment into lymph nodes

TitleAdhesive mechanisms governing interferon-producing cell recruitment into lymph nodes
Authors
Issue Date2005
Citation
Journal of Experimental Medicine, 2005, v. 202, n. 5, p. 687-696 How to Cite?
AbstractNatural interferon-producing cells (IPCs) are found in peripheral lymph nodes (PLNs), where they support NK cell, T cell, and B cell responses to pathogens. However, their route of entry and the adhesive mechanisms used to gain access to PLNs remain poorly defined. We report that IPCs can enter PLNs via a hematogenous route, which involves a multistep adhesive process, and that transmigration is enhanced by inflammation. Results indicate that L-selectin on IPCs is required for efficient attachment and rolling on high endothelial venules in vivo in both nonstimulated and inflamed PLNs. IPCs, however, also possess functional ligands for E-selectin that contribute to this process only in the latter case. In conjunction with selectin-mediated adhesion, both β1- and β2-integrins participate in IPC attachment to the inflamed vessel wall, whereas chemotaxis relies in part on the chemokine receptor CCR5. Identification of the adhesive machinery required for IPC trafficking into PLNs may provide opportunities to regulate immune responses reliant on the activity of these cells. JEM © The Rockefeller University Press.
Persistent Identifierhttp://hdl.handle.net/10722/292536
ISSN
2023 Impact Factor: 12.6
2023 SCImago Journal Rankings: 6.838
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorDiacovo, Thomas G.-
dc.contributor.authorBlasius, Amanda L.-
dc.contributor.authorMak, Tak W.-
dc.contributor.authorCella, Marina-
dc.contributor.authorColonna, Marco-
dc.date.accessioned2020-11-17T14:56:41Z-
dc.date.available2020-11-17T14:56:41Z-
dc.date.issued2005-
dc.identifier.citationJournal of Experimental Medicine, 2005, v. 202, n. 5, p. 687-696-
dc.identifier.issn0022-1007-
dc.identifier.urihttp://hdl.handle.net/10722/292536-
dc.description.abstractNatural interferon-producing cells (IPCs) are found in peripheral lymph nodes (PLNs), where they support NK cell, T cell, and B cell responses to pathogens. However, their route of entry and the adhesive mechanisms used to gain access to PLNs remain poorly defined. We report that IPCs can enter PLNs via a hematogenous route, which involves a multistep adhesive process, and that transmigration is enhanced by inflammation. Results indicate that L-selectin on IPCs is required for efficient attachment and rolling on high endothelial venules in vivo in both nonstimulated and inflamed PLNs. IPCs, however, also possess functional ligands for E-selectin that contribute to this process only in the latter case. In conjunction with selectin-mediated adhesion, both β1- and β2-integrins participate in IPC attachment to the inflamed vessel wall, whereas chemotaxis relies in part on the chemokine receptor CCR5. Identification of the adhesive machinery required for IPC trafficking into PLNs may provide opportunities to regulate immune responses reliant on the activity of these cells. JEM © The Rockefeller University Press.-
dc.languageeng-
dc.relation.ispartofJournal of Experimental Medicine-
dc.titleAdhesive mechanisms governing interferon-producing cell recruitment into lymph nodes-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1084/jem.20051035-
dc.identifier.pmid16147979-
dc.identifier.pmcidPMC2212867-
dc.identifier.scopuseid_2-s2.0-24344450308-
dc.identifier.volume202-
dc.identifier.issue5-
dc.identifier.spage687-
dc.identifier.epage696-
dc.identifier.eissn0022-1007-
dc.identifier.isiWOS:000231962700012-
dc.identifier.issnl0022-1007-

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