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Article: Critical role of CD28 in protective immunity against Salmonella typhimurium

TitleCritical role of CD28 in protective immunity against Salmonella typhimurium
Authors
Issue Date1999
Citation
Journal of Immunology, 1999, v. 163, n. 12, p. 6769-6776 How to Cite?
AbstractEfficient T cell activation requires both TCR signals and costimulatory signals. CD28 is one of the molecules that provide costimulatory signals for T cells. We used mice deficient in CD28 expression (CD28(-/-) mice) to analyze the role of CD28 in the immune response against the intracellular bacterium Salmonella typhimurium, the causative agent of murine typhoid fever. CD28(-/-) mice were highly susceptible to infection with wild-type S. typhimurium and even failed to control infection with attenuated aroA- S. typhimurium. More detailed analysis revealed that CD28(-/-) animals did not mount a T-dependent Ab response and were highly impaired in the production of IFN-γ. Thus, CD28 cosignaling is crucial for immunity against S. typhimurium. To our knowledge, this is the first report describing an essential role for CD28 in protective immunity against an intracellular microbial pathogen.
Persistent Identifierhttp://hdl.handle.net/10722/292527
ISSN
2023 Impact Factor: 3.6
2023 SCImago Journal Rankings: 1.558
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMittrücker, Hans Willi-
dc.contributor.authorKöhler, Anne-
dc.contributor.authorMak, Tak W.-
dc.contributor.authorKaufmann, Stefan H.E.-
dc.date.accessioned2020-11-17T14:56:40Z-
dc.date.available2020-11-17T14:56:40Z-
dc.date.issued1999-
dc.identifier.citationJournal of Immunology, 1999, v. 163, n. 12, p. 6769-6776-
dc.identifier.issn0022-1767-
dc.identifier.urihttp://hdl.handle.net/10722/292527-
dc.description.abstractEfficient T cell activation requires both TCR signals and costimulatory signals. CD28 is one of the molecules that provide costimulatory signals for T cells. We used mice deficient in CD28 expression (CD28(-/-) mice) to analyze the role of CD28 in the immune response against the intracellular bacterium Salmonella typhimurium, the causative agent of murine typhoid fever. CD28(-/-) mice were highly susceptible to infection with wild-type S. typhimurium and even failed to control infection with attenuated aroA- S. typhimurium. More detailed analysis revealed that CD28(-/-) animals did not mount a T-dependent Ab response and were highly impaired in the production of IFN-γ. Thus, CD28 cosignaling is crucial for immunity against S. typhimurium. To our knowledge, this is the first report describing an essential role for CD28 in protective immunity against an intracellular microbial pathogen.-
dc.languageeng-
dc.relation.ispartofJournal of Immunology-
dc.titleCritical role of CD28 in protective immunity against Salmonella typhimurium-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.pmid10586076-
dc.identifier.scopuseid_2-s2.0-0344614706-
dc.identifier.volume163-
dc.identifier.issue12-
dc.identifier.spage6769-
dc.identifier.epage6776-
dc.identifier.isiWOS:000084134200054-
dc.identifier.issnl0022-1767-

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