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- Publisher Website: 10.1016/S0300-9572(01)00444-0
- Scopus: eid_2-s2.0-0036179555
- PMID: 11841880
- WOS: WOS:000174397700001
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Article: L-selectin in health and disease
Title | L-selectin in health and disease |
---|---|
Authors | |
Keywords | Adhesion molecules L-selectin Neutrophils Leucocytes Lymphocytes CD62L Monocytes |
Issue Date | 2002 |
Citation | Resuscitation, 2002, v. 52, n. 2, p. 127-141 How to Cite? |
Abstract | This article reviews recent advances in the knowledge of the role of L-selectin, an adhesion molecule that is expressed on the surface of circulating leucocytes, in animal and human physiology and pathophysiology. After a brief discussion on nomenclature and structure, it progresses through the evidence for expression and regulation of L-selectin, cell collection and purification, physiological function and roles. The special role of knock out mice and monoclonal antibodies in determining a role for L-selectin in inflammatory states is described before proceeding to discuss the importance of L-selectin ligands and shed L-selectin. A second section describes a role for L-selectin in pathophysiological states in animals and man, with special reference to trauma, systemic inflammatory syndromes and sepsis. The review concludes with a summary of the potential role of anti-inflammatory medication and L-selectin blockers in the management of inflammation. © 2002 Elsevier Science Ireland Ltd. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/292518 |
ISSN | 2023 Impact Factor: 6.5 2023 SCImago Journal Rankings: 2.363 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Rainer, Timothy H. | - |
dc.date.accessioned | 2020-11-17T14:56:39Z | - |
dc.date.available | 2020-11-17T14:56:39Z | - |
dc.date.issued | 2002 | - |
dc.identifier.citation | Resuscitation, 2002, v. 52, n. 2, p. 127-141 | - |
dc.identifier.issn | 0300-9572 | - |
dc.identifier.uri | http://hdl.handle.net/10722/292518 | - |
dc.description.abstract | This article reviews recent advances in the knowledge of the role of L-selectin, an adhesion molecule that is expressed on the surface of circulating leucocytes, in animal and human physiology and pathophysiology. After a brief discussion on nomenclature and structure, it progresses through the evidence for expression and regulation of L-selectin, cell collection and purification, physiological function and roles. The special role of knock out mice and monoclonal antibodies in determining a role for L-selectin in inflammatory states is described before proceeding to discuss the importance of L-selectin ligands and shed L-selectin. A second section describes a role for L-selectin in pathophysiological states in animals and man, with special reference to trauma, systemic inflammatory syndromes and sepsis. The review concludes with a summary of the potential role of anti-inflammatory medication and L-selectin blockers in the management of inflammation. © 2002 Elsevier Science Ireland Ltd. All rights reserved. | - |
dc.language | eng | - |
dc.relation.ispartof | Resuscitation | - |
dc.subject | Adhesion molecules | - |
dc.subject | L-selectin | - |
dc.subject | Neutrophils | - |
dc.subject | Leucocytes | - |
dc.subject | Lymphocytes | - |
dc.subject | CD62L | - |
dc.subject | Monocytes | - |
dc.title | L-selectin in health and disease | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/S0300-9572(01)00444-0 | - |
dc.identifier.pmid | 11841880 | - |
dc.identifier.scopus | eid_2-s2.0-0036179555 | - |
dc.identifier.volume | 52 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 127 | - |
dc.identifier.epage | 141 | - |
dc.identifier.isi | WOS:000174397700001 | - |
dc.identifier.issnl | 0300-9572 | - |