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Article: A new family of regulators of G-protein-coupled receptors?

TitleA new family of regulators of G-protein-coupled receptors?
Authors
Issue Date1996
Citation
Current Biology, 1996, v. 6, n. 2, p. 211-212 How to Cite?
AbstractOrganisms as diverse as fungi and humans use G-protein-coupled receptors to control signal transduction pathways responsive to various hormones, neuroregulatory molecules and other sensory stimuli [1]. Continual stimulation of these receptors often leads to their desensitization, which is mediated in part by the consecutive actions of two families of proteins - the G-protein-coupled receptor kinases, which phosphorylate the agonist-occupied receptors [2], and the arrestin proteins, which subsequently bind to the receptors [3]. We now present evidence that a group of proteins - the G0S8/Sst2p family - may be a third class of receptor-desensitizing factors.
Persistent Identifierhttp://hdl.handle.net/10722/292510
ISSN
2023 Impact Factor: 8.1
2023 SCImago Journal Rankings: 2.982
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSiderovski, David P.-
dc.contributor.authorHessel, Andrew-
dc.contributor.authorChung, Stephen-
dc.contributor.authorMak, Tak W.-
dc.contributor.authorTyers, Michael-
dc.date.accessioned2020-11-17T14:56:38Z-
dc.date.available2020-11-17T14:56:38Z-
dc.date.issued1996-
dc.identifier.citationCurrent Biology, 1996, v. 6, n. 2, p. 211-212-
dc.identifier.issn0960-9822-
dc.identifier.urihttp://hdl.handle.net/10722/292510-
dc.description.abstractOrganisms as diverse as fungi and humans use G-protein-coupled receptors to control signal transduction pathways responsive to various hormones, neuroregulatory molecules and other sensory stimuli [1]. Continual stimulation of these receptors often leads to their desensitization, which is mediated in part by the consecutive actions of two families of proteins - the G-protein-coupled receptor kinases, which phosphorylate the agonist-occupied receptors [2], and the arrestin proteins, which subsequently bind to the receptors [3]. We now present evidence that a group of proteins - the G0S8/Sst2p family - may be a third class of receptor-desensitizing factors.-
dc.languageeng-
dc.relation.ispartofCurrent Biology-
dc.titleA new family of regulators of G-protein-coupled receptors?-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/S0960-9822(02)00454-2-
dc.identifier.pmid8673468-
dc.identifier.scopuseid_2-s2.0-0030087943-
dc.identifier.volume6-
dc.identifier.issue2-
dc.identifier.spage211-
dc.identifier.epage212-
dc.identifier.isiWOS:A1996TW19500025-
dc.identifier.issnl0960-9822-

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