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Article: Skin allograft rejection in CD28-deficient mice

TitleSkin allograft rejection in CD28-deficient mice
Authors
Issue Date1996
Citation
Transplantation, 1996, v. 61, n. 3, p. 352-355 How to Cite?
AbstractCostimulatory interactions between CD28 and the B7 family have been shown to augment T cell responses in general. To further assess the importance of the costimulatory signals generated through CD28, the allogeneic response was examined in CD28-deficient mice. T cells from CD28-deficient mice showed reduced proliferation and cytokine production in response to allogeneic stimulator cells in vitro. However, CD28-deficient T cells developed cytotoxic activity against allogeneic target cells in vitro and efficiently rejected skin allografts in vivo. These results suggest that the costimulatory signals through CD28 are not essential for the induction of alloreactive effector functions in vitro or in vivo.
Persistent Identifierhttp://hdl.handle.net/10722/292508
ISSN
2023 Impact Factor: 5.3
2023 SCImago Journal Rankings: 1.371
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKawai, Kazuhiro-
dc.contributor.authorShahinian, Arda-
dc.contributor.authorMak, Tak W.-
dc.contributor.authorOhashi, Pamela S.-
dc.date.accessioned2020-11-17T14:56:38Z-
dc.date.available2020-11-17T14:56:38Z-
dc.date.issued1996-
dc.identifier.citationTransplantation, 1996, v. 61, n. 3, p. 352-355-
dc.identifier.issn0041-1337-
dc.identifier.urihttp://hdl.handle.net/10722/292508-
dc.description.abstractCostimulatory interactions between CD28 and the B7 family have been shown to augment T cell responses in general. To further assess the importance of the costimulatory signals generated through CD28, the allogeneic response was examined in CD28-deficient mice. T cells from CD28-deficient mice showed reduced proliferation and cytokine production in response to allogeneic stimulator cells in vitro. However, CD28-deficient T cells developed cytotoxic activity against allogeneic target cells in vitro and efficiently rejected skin allografts in vivo. These results suggest that the costimulatory signals through CD28 are not essential for the induction of alloreactive effector functions in vitro or in vivo.-
dc.languageeng-
dc.relation.ispartofTransplantation-
dc.titleSkin allograft rejection in CD28-deficient mice-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/00007890-199602150-00003-
dc.identifier.pmid8610339-
dc.identifier.scopuseid_2-s2.0-0030064426-
dc.identifier.volume61-
dc.identifier.issue3-
dc.identifier.spage352-
dc.identifier.epage355-
dc.identifier.isiWOS:A1996TW44600003-
dc.identifier.issnl0041-1337-

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