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Article: Collagen-induced arthritis in CD4- or CD8-deficient mice: CD8+ T cells play a role in initiation and regulate recovery phase of collagen-induced arthritis

TitleCollagen-induced arthritis in CD4- or CD8-deficient mice: CD8<sup>+</sup> T cells play a role in initiation and regulate recovery phase of collagen-induced arthritis
Authors
Issue Date1996
Citation
Journal of Immunology, 1996, v. 156, n. 11, p. 4520-4526 How to Cite?
AbstractCollagen-induced arthritis (CIA) is an experimental autoimmune disease induced by immunization with collagen type II (CII). We studied CIA in CD4- or CD8-deficient DBA/1 mice to further define the roles of CD4+ and CD8+ T cells in the disease. CD4-deficient mice developed severe arthritis, and no differences in incidence, clinical course, and severity were observed between CD4 -/- and CD4 +/- mice. Proliferative responses of lymph node T cells to CII was, however, reduced in CD4 -/- mice, and inflamed joints revealed relative accumulation of CD4-CD8-TCRαβ+ cells. A CII-specific T cell line generated from CD4-deficient mice responded to CII in a MHC-restricted fashion and had a CD4-CD8-TCRαβ+ phenotype. Disease incidence in CD8 - /- mice was significantly decreased compared with CD8 +/- mice, even though the severity of arthritis in arthritic mice was not different. These results suggests a role for CD8+ T cells in initiating CIA. Interestingly, CD8- deficient mice were more susceptible to a second induction of arthritis after remission of initial disease, pointing towards an immunoregulatory role for CD8+ T cells. CD8-deficient mice did not, however, show any defect in oral tolerance induction using CII. Taken together, our findings demonstrate that CD4-CD8-TCRαβ cells can trigger systemic arthritis in CD4-deficient mice and that CD8+ T cells can play dual and opposing roles, important both in initiation of CIA and in providing resistance to reinduction of CIA after recovery from initial disease.
Persistent Identifierhttp://hdl.handle.net/10722/292503
ISSN
2023 Impact Factor: 3.6
2023 SCImago Journal Rankings: 1.558
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTada, Yoshifumi-
dc.contributor.authorHo, Alexandra-
dc.contributor.authorKoh, Dow Rhoon-
dc.contributor.authorMak, Tak W.-
dc.date.accessioned2020-11-17T14:56:37Z-
dc.date.available2020-11-17T14:56:37Z-
dc.date.issued1996-
dc.identifier.citationJournal of Immunology, 1996, v. 156, n. 11, p. 4520-4526-
dc.identifier.issn0022-1767-
dc.identifier.urihttp://hdl.handle.net/10722/292503-
dc.description.abstractCollagen-induced arthritis (CIA) is an experimental autoimmune disease induced by immunization with collagen type II (CII). We studied CIA in CD4- or CD8-deficient DBA/1 mice to further define the roles of CD4+ and CD8+ T cells in the disease. CD4-deficient mice developed severe arthritis, and no differences in incidence, clinical course, and severity were observed between CD4 -/- and CD4 +/- mice. Proliferative responses of lymph node T cells to CII was, however, reduced in CD4 -/- mice, and inflamed joints revealed relative accumulation of CD4-CD8-TCRαβ+ cells. A CII-specific T cell line generated from CD4-deficient mice responded to CII in a MHC-restricted fashion and had a CD4-CD8-TCRαβ+ phenotype. Disease incidence in CD8 - /- mice was significantly decreased compared with CD8 +/- mice, even though the severity of arthritis in arthritic mice was not different. These results suggests a role for CD8+ T cells in initiating CIA. Interestingly, CD8- deficient mice were more susceptible to a second induction of arthritis after remission of initial disease, pointing towards an immunoregulatory role for CD8+ T cells. CD8-deficient mice did not, however, show any defect in oral tolerance induction using CII. Taken together, our findings demonstrate that CD4-CD8-TCRαβ cells can trigger systemic arthritis in CD4-deficient mice and that CD8+ T cells can play dual and opposing roles, important both in initiation of CIA and in providing resistance to reinduction of CIA after recovery from initial disease.-
dc.languageeng-
dc.relation.ispartofJournal of Immunology-
dc.titleCollagen-induced arthritis in CD4- or CD8-deficient mice: CD8<sup>+</sup> T cells play a role in initiation and regulate recovery phase of collagen-induced arthritis-
dc.typeArticle-
dc.identifier.pmid8666829-
dc.identifier.scopuseid_2-s2.0-0030010969-
dc.identifier.volume156-
dc.identifier.issue11-
dc.identifier.spage4520-
dc.identifier.epage4526-
dc.identifier.isiWOS:A1996UM24400060-
dc.identifier.issnl0022-1767-

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