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Article: Requirement for transcription factor IRF-1 in NO synthase induction in macrophages

TitleRequirement for transcription factor IRF-1 in NO synthase induction in macrophages
Authors
Kamijo, R.Harada, H.Matsuyama, T.Bosland, M.Gerecitano, J.Shapiro, D.Le, J.Koh, S. I.Kimura, T.Green, S. J.Mak, T. W.Taniguchi, T.Vilček, J.
Issue Date1994
Citation
Science, 1994, v. 263, n. 5153, p. 1612-1615 How to Cite?
DOI: http://dx.doi.org/10.1126/science.7510419
AbstractProduction of nitric oxide (NO) by macrophages is important for the killing of intracellular infectious agents. Interferon (IFN)-γ and lipopolysaccharide stimulate NO production by transcriptionally up-regulating the inducible NO synthase (iNOS). Macrophages from mice with a targeted disruption of the IFN regulatory factor-1 (IRF-1) gene (IRF-I-/- mice) produced little or no NO and synthesized barely detectable iNOS messenger RNA in response to stimulation. Two adjacent IRF-1 response elements were identified in the iNOS promoter. Infection with Mycobacterium bovis (BCG) was more severe in IRF-1-/- mice than in wild-type mice. Thus, IRF-1 is essential for iNOS activation in murine macrophages.
Persistent Identifierhttp://hdl.handle.net/10722/292449
ISSN
0036-8075
2023 Impact Factor: 44.7
2023 SCImago Journal Rankings: 11.902
ISI Accession Number ID
WOS:A1994NB67300032

 

DC FieldValueLanguage
dc.contributor.authorKamijo, R.-
dc.contributor.authorHarada, H.-
dc.contributor.authorMatsuyama, T.-
dc.contributor.authorBosland, M.-
dc.contributor.authorGerecitano, J.-
dc.contributor.authorShapiro, D.-
dc.contributor.authorLe, J.-
dc.contributor.authorKoh, S. I.-
dc.contributor.authorKimura, T.-
dc.contributor.authorGreen, S. J.-
dc.contributor.authorMak, T. W.-
dc.contributor.authorTaniguchi, T.-
dc.contributor.authorVilček, J.-
dc.date.accessioned2020-11-17T14:56:30Z-
dc.date.available2020-11-17T14:56:30Z-
dc.date.issued1994-
dc.identifier.citationScience, 1994, v. 263, n. 5153, p. 1612-1615-
dc.identifier.issn0036-8075-
dc.identifier.urihttp://hdl.handle.net/10722/292449-
dc.description.abstractProduction of nitric oxide (NO) by macrophages is important for the killing of intracellular infectious agents. Interferon (IFN)-γ and lipopolysaccharide stimulate NO production by transcriptionally up-regulating the inducible NO synthase (iNOS). Macrophages from mice with a targeted disruption of the IFN regulatory factor-1 (IRF-1) gene (IRF-I-/- mice) produced little or no NO and synthesized barely detectable iNOS messenger RNA in response to stimulation. Two adjacent IRF-1 response elements were identified in the iNOS promoter. Infection with Mycobacterium bovis (BCG) was more severe in IRF-1-/- mice than in wild-type mice. Thus, IRF-1 is essential for iNOS activation in murine macrophages.-
dc.languageeng-
dc.relation.ispartofScience-
dc.titleRequirement for transcription factor IRF-1 in NO synthase induction in macrophages-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1126/science.7510419-
dc.identifier.pmid7510419-
dc.identifier.scopuseid_2-s2.0-0028348307-
dc.identifier.volume263-
dc.identifier.issue5153-
dc.identifier.spage1612-
dc.identifier.epage1615-
dc.identifier.isiWOS:A1994NB67300032-
dc.identifier.issnl0036-8075-

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