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- Publisher Website: 10.1146/annurev.iy.12.040194.002055
- Scopus: eid_2-s2.0-0028288925
- PMID: 7912088
- WOS: WOS:A1994NF48700012
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Article: Lymphocyte ontogeny and activation in gene targeted mutant mice
Title | Lymphocyte ontogeny and activation in gene targeted mutant mice |
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Authors | |
Keywords | immune response cytokines embryonic stem cells (ES cells) lymphocyte signaling homologous recombination |
Issue Date | 1994 |
Citation | Annual Review of Immunology, 1994, v. 12, p. 367-411 How to Cite? |
Abstract | Gene targeting by homologous recombination in pluripotent embryonic stem cells enabled the systematic creation of mouse strains with defined genetic alterations. During the past few years a rapidly growing number of gene targeted mice has provided new insights into development, selection, activation, and signaling of T and B cells, as well as into the functions of cytokines. Here we discuss the present state of targeting technology and summarize the phenotypic changes observed in gene targeted mouse strains of immunological interest. These data allow us for the first time to define genetic checkpoints in lymphocyte development that are crucial for the orderly progression of T and B cells through ontogeny and for the generation of an immune response. |
Persistent Identifier | http://hdl.handle.net/10722/292446 |
ISSN | 2023 Impact Factor: 26.9 2023 SCImago Journal Rankings: 15.620 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Pfeffer, K. | - |
dc.contributor.author | Mak, T. W. | - |
dc.date.accessioned | 2020-11-17T14:56:30Z | - |
dc.date.available | 2020-11-17T14:56:30Z | - |
dc.date.issued | 1994 | - |
dc.identifier.citation | Annual Review of Immunology, 1994, v. 12, p. 367-411 | - |
dc.identifier.issn | 0732-0582 | - |
dc.identifier.uri | http://hdl.handle.net/10722/292446 | - |
dc.description.abstract | Gene targeting by homologous recombination in pluripotent embryonic stem cells enabled the systematic creation of mouse strains with defined genetic alterations. During the past few years a rapidly growing number of gene targeted mice has provided new insights into development, selection, activation, and signaling of T and B cells, as well as into the functions of cytokines. Here we discuss the present state of targeting technology and summarize the phenotypic changes observed in gene targeted mouse strains of immunological interest. These data allow us for the first time to define genetic checkpoints in lymphocyte development that are crucial for the orderly progression of T and B cells through ontogeny and for the generation of an immune response. | - |
dc.language | eng | - |
dc.relation.ispartof | Annual Review of Immunology | - |
dc.subject | immune response | - |
dc.subject | cytokines | - |
dc.subject | embryonic stem cells (ES cells) | - |
dc.subject | lymphocyte signaling | - |
dc.subject | homologous recombination | - |
dc.title | Lymphocyte ontogeny and activation in gene targeted mutant mice | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1146/annurev.iy.12.040194.002055 | - |
dc.identifier.pmid | 7912088 | - |
dc.identifier.scopus | eid_2-s2.0-0028288925 | - |
dc.identifier.volume | 12 | - |
dc.identifier.spage | 367 | - |
dc.identifier.epage | 411 | - |
dc.identifier.isi | WOS:A1994NF48700012 | - |
dc.identifier.issnl | 0732-0582 | - |