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Article: Involvement of the IRF-1 transcription factor in antiviral responses to interferons

TitleInvolvement of the IRF-1 transcription factor in antiviral responses to interferons
Authors
Issue Date1994
Citation
Science, 1994, v. 264, n. 5167, p. 1921-1924 How to Cite?
AbstractThe mechanisms underlying interferon (IFN)-induced antiviral states are not well understood. Interferon regulatory factor-1 (IRF-1) is an IFN-inducible transcriptional activator, whereas IRF-2 suppresses IRF-1 action. The inhibition of encephalomyocarditis virus (EMCV) replication by IFN-α and especially by IFN-γ was impaired in cells from mice with a null mutation in the IRF-1 gene (IRF-1-/- mice). The IRF-1-/- mice were less resistant than normal mice to EMCV infection, as revealed by accelerated mortality and a larger virus titer in target organs. The absence of IRF-1 did not clearly affect replication of two other types of viruses. Thus, IRF-1 is necessary for the antiviral action of IFNs against some viruses, but IFNs activate multiple activation pathways through diverse target genes to induce the antiviral state.
Persistent Identifierhttp://hdl.handle.net/10722/292439
ISSN
2023 Impact Factor: 44.7
2023 SCImago Journal Rankings: 11.902
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKimura, Tohru-
dc.contributor.authorNakayama, Katsutoshi-
dc.contributor.authorPenninger, Josef-
dc.contributor.authorKitagawa, Motoo-
dc.contributor.authorHarada, Hisashi-
dc.contributor.authorMatsuyama, Toshifumi-
dc.contributor.authorTanaka, Nobuyuki-
dc.contributor.authorKamijo, Ryutaro-
dc.contributor.authorVilček, Jan-
dc.contributor.authorMak, Tak W.-
dc.contributor.authorTaniguchi, Tadatsugu-
dc.date.accessioned2020-11-17T14:56:29Z-
dc.date.available2020-11-17T14:56:29Z-
dc.date.issued1994-
dc.identifier.citationScience, 1994, v. 264, n. 5167, p. 1921-1924-
dc.identifier.issn0036-8075-
dc.identifier.urihttp://hdl.handle.net/10722/292439-
dc.description.abstractThe mechanisms underlying interferon (IFN)-induced antiviral states are not well understood. Interferon regulatory factor-1 (IRF-1) is an IFN-inducible transcriptional activator, whereas IRF-2 suppresses IRF-1 action. The inhibition of encephalomyocarditis virus (EMCV) replication by IFN-α and especially by IFN-γ was impaired in cells from mice with a null mutation in the IRF-1 gene (IRF-1-/- mice). The IRF-1-/- mice were less resistant than normal mice to EMCV infection, as revealed by accelerated mortality and a larger virus titer in target organs. The absence of IRF-1 did not clearly affect replication of two other types of viruses. Thus, IRF-1 is necessary for the antiviral action of IFNs against some viruses, but IFNs activate multiple activation pathways through diverse target genes to induce the antiviral state.-
dc.languageeng-
dc.relation.ispartofScience-
dc.titleInvolvement of the IRF-1 transcription factor in antiviral responses to interferons-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1126/science.8009222-
dc.identifier.pmid8009222-
dc.identifier.scopuseid_2-s2.0-0028146097-
dc.identifier.volume264-
dc.identifier.issue5167-
dc.identifier.spage1921-
dc.identifier.epage1924-
dc.identifier.isiWOS:A1994NT84700042-
dc.identifier.issnl0036-8075-

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