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Article: Tolerance and self-reactivity in vγ1.1cγ4 transgenic mice

TitleTolerance and self-reactivity in vγ1.1cγ4 transgenic mice
Authors
KeywordsThymus
Self-reactivity
T-cell
Tolerance
Transgenic
Issue Date1994
Citation
International Reviews of Immunology, 1994, v. 11, n. 4, p. 295-304 How to Cite?
AbstractImmunological tolerance is the process of inhibiting or eliminating lymphocytes that recognize self-derived antigens. By removing potentially harmful self-reactive clones, this mechanism allows for the random generation of a diverse repertoire of T-cells capable of responding to foreign pathogens. Although all self-reactive T-cells should be removed from the repertoire, it is quite clear from many recent studies that a significant fraction of T-cells bearing γdelta; T-cell receptors (TCR) recognize self-derived antigens in normal healthy mice. The presence of self-reactive T-cells in healthy animals presents a paradox which may be explained by understanding the transient expression of the antigens (e.g., MHC class 1b, Heat Shock Proteins) that have been identified for γdelta; T-cells thus far. Data from experiments with VγI. 1C-γ4 transgenic mice demonstrating the presence of self-reactive 78 T-cells and their influence on lymphoid development and immune surveillance will be examined in this review. © 1994 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
Persistent Identifierhttp://hdl.handle.net/10722/292432
ISSN
2023 Impact Factor: 4.3
2023 SCImago Journal Rankings: 1.135

 

DC FieldValueLanguage
dc.contributor.authorFerrick, David A.-
dc.contributor.authorGemmell-Hori, Lorraine-
dc.contributor.authorSydora, Beate-
dc.contributor.authorMulvania, Thera-
dc.contributor.authorPenninger, Josef M.-
dc.contributor.authorKronenberg, Mitchell-
dc.contributor.authorMak, Tak W.-
dc.date.accessioned2020-11-17T14:56:28Z-
dc.date.available2020-11-17T14:56:28Z-
dc.date.issued1994-
dc.identifier.citationInternational Reviews of Immunology, 1994, v. 11, n. 4, p. 295-304-
dc.identifier.issn0883-0185-
dc.identifier.urihttp://hdl.handle.net/10722/292432-
dc.description.abstractImmunological tolerance is the process of inhibiting or eliminating lymphocytes that recognize self-derived antigens. By removing potentially harmful self-reactive clones, this mechanism allows for the random generation of a diverse repertoire of T-cells capable of responding to foreign pathogens. Although all self-reactive T-cells should be removed from the repertoire, it is quite clear from many recent studies that a significant fraction of T-cells bearing γdelta; T-cell receptors (TCR) recognize self-derived antigens in normal healthy mice. The presence of self-reactive T-cells in healthy animals presents a paradox which may be explained by understanding the transient expression of the antigens (e.g., MHC class 1b, Heat Shock Proteins) that have been identified for γdelta; T-cells thus far. Data from experiments with VγI. 1C-γ4 transgenic mice demonstrating the presence of self-reactive 78 T-cells and their influence on lymphoid development and immune surveillance will be examined in this review. © 1994 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.-
dc.languageeng-
dc.relation.ispartofInternational Reviews of Immunology-
dc.subjectThymus-
dc.subjectSelf-reactivity-
dc.subjectT-cell-
dc.subjectTolerance-
dc.subjectTransgenic-
dc.titleTolerance and self-reactivity in vγ1.1cγ4 transgenic mice-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.3109/08830189409051176-
dc.identifier.pmid7806943-
dc.identifier.scopuseid_2-s2.0-0028065649-
dc.identifier.volume11-
dc.identifier.issue4-
dc.identifier.spage295-
dc.identifier.epage304-
dc.identifier.issnl0883-0185-

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