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- Publisher Website: 10.1016/0092-8674(93)90400-K
- Scopus: eid_2-s2.0-0027497985
- PMID: 8453666
- WOS: WOS:A1993KR43600008
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Article: CD8 is critically involved in lymphocyte activation by a T. brucei brucei-released molecule
Title | CD8 is critically involved in lymphocyte activation by a T. brucei brucei-released molecule |
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Authors | |
Issue Date | 1993 |
Citation | Cell, 1993, v. 72, n. 5, p. 715-727 How to Cite? |
Abstract | T. brucei brucei released a lymphocyte triggering factor (TLTF), which triggered purified CD8+, but not CD4+, T cells to interferon γ (IFN-γ) mRNA expression and secretion and to [3H]thymidine incorporation. TLTF also induced mRNA for transforming growth factor β, but not for interleukin-4. The action of this TLTF on mononuclear cell (MNC) cultures was blocked by anti-CD8 antibodies and by soluble CD8. MNCs from a mutant mouse strain lacking CD8 expression were not triggered by TLTF. IFN-γ provides a growth stimulus for T. brucei brucei, and infected CD8- mice had much lower parasitemia and survived longer than CD8+ mice. The host-parasite interaction in experimental African trypanosomiasis thus involves parasite release of TLTF, which by binding to CD8 triggers CD8+ cells to produce the parasite growth-promoting cytokine IFN-γ. © 1993. |
Persistent Identifier | http://hdl.handle.net/10722/292423 |
ISSN | 2023 Impact Factor: 45.5 2023 SCImago Journal Rankings: 24.342 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Olsson, Tomas | - |
dc.contributor.author | Bakhiet, Moiz | - |
dc.contributor.author | Höjeberg, Bo | - |
dc.contributor.author | Ljungdahl, Åke | - |
dc.contributor.author | Edlund, Conny | - |
dc.contributor.author | Andersson, Gudrun | - |
dc.contributor.author | Ekre, Hans Peter | - |
dc.contributor.author | Fung-Leung, Wai Ping | - |
dc.contributor.author | Mak, Tak | - |
dc.contributor.author | Wigzell, Hans | - |
dc.contributor.author | Fiszer, Urszula | - |
dc.contributor.author | Kristensson, Krister | - |
dc.date.accessioned | 2020-11-17T14:56:27Z | - |
dc.date.available | 2020-11-17T14:56:27Z | - |
dc.date.issued | 1993 | - |
dc.identifier.citation | Cell, 1993, v. 72, n. 5, p. 715-727 | - |
dc.identifier.issn | 0092-8674 | - |
dc.identifier.uri | http://hdl.handle.net/10722/292423 | - |
dc.description.abstract | T. brucei brucei released a lymphocyte triggering factor (TLTF), which triggered purified CD8+, but not CD4+, T cells to interferon γ (IFN-γ) mRNA expression and secretion and to [3H]thymidine incorporation. TLTF also induced mRNA for transforming growth factor β, but not for interleukin-4. The action of this TLTF on mononuclear cell (MNC) cultures was blocked by anti-CD8 antibodies and by soluble CD8. MNCs from a mutant mouse strain lacking CD8 expression were not triggered by TLTF. IFN-γ provides a growth stimulus for T. brucei brucei, and infected CD8- mice had much lower parasitemia and survived longer than CD8+ mice. The host-parasite interaction in experimental African trypanosomiasis thus involves parasite release of TLTF, which by binding to CD8 triggers CD8+ cells to produce the parasite growth-promoting cytokine IFN-γ. © 1993. | - |
dc.language | eng | - |
dc.relation.ispartof | Cell | - |
dc.title | CD8 is critically involved in lymphocyte activation by a T. brucei brucei-released molecule | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1016/0092-8674(93)90400-K | - |
dc.identifier.pmid | 8453666 | - |
dc.identifier.scopus | eid_2-s2.0-0027497985 | - |
dc.identifier.volume | 72 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | 715 | - |
dc.identifier.epage | 727 | - |
dc.identifier.isi | WOS:A1993KR43600008 | - |
dc.identifier.issnl | 0092-8674 | - |