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Article: Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection

TitleMice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection
Authors
Issue Date1993
Citation
Cell, 1993, v. 73, n. 3, p. 457-467 How to Cite?
AbstractThe multiple biological activities of tumor necrosis factor (TNF) are mediated by two distinct cell surface receptors of 55 kd (TNFRp55) and 75 kd (TNFRp75). Using gene targeting, we generated a TNFRp55-deficient mouse strain. Cells from TNFRp55-/- mutant mice lack expression of TNFRp55 but display normal numbers of high affinity TNFRp75 molecules. Thymocyte development and lymphocyte populations are unaltered, and clonal deletion of potentially self-reactive T cells is not impaired. However, TNF signaling is largely abolished, as judged by the failure of TNF to induce NF-κB in T lymphocytes from TNFRp55-deficient The loss of TNFRp55 function renders mice resistant to lethal dosages of either lipopolysaccharides or S. aureus enterotoxin B. In contrast, TNFRp55-deficient mice are severely impaired to clear L. monocytogenes and readily succumb to infection. Thus, the 55 kd TNFR plays a decisive role in the host's defense against microorganisms and their pathogenic factors. © 1993.
Persistent Identifierhttp://hdl.handle.net/10722/292410
ISSN
2023 Impact Factor: 45.5
2023 SCImago Journal Rankings: 24.342
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorPfeffer, Klaus-
dc.contributor.authorMatsuyama, Toshifumi-
dc.contributor.authorKündig, Thomas M.-
dc.contributor.authorWakeham, Andrew-
dc.contributor.authorKishihara, Kenji-
dc.contributor.authorShahinian, Arda-
dc.contributor.authorWiegmann, Katja-
dc.contributor.authorOhashi, Pamela S.-
dc.contributor.authorKrönke, Martin-
dc.contributor.authorMak, Tak W.-
dc.date.accessioned2020-11-17T14:56:26Z-
dc.date.available2020-11-17T14:56:26Z-
dc.date.issued1993-
dc.identifier.citationCell, 1993, v. 73, n. 3, p. 457-467-
dc.identifier.issn0092-8674-
dc.identifier.urihttp://hdl.handle.net/10722/292410-
dc.description.abstractThe multiple biological activities of tumor necrosis factor (TNF) are mediated by two distinct cell surface receptors of 55 kd (TNFRp55) and 75 kd (TNFRp75). Using gene targeting, we generated a TNFRp55-deficient mouse strain. Cells from TNFRp55-/- mutant mice lack expression of TNFRp55 but display normal numbers of high affinity TNFRp75 molecules. Thymocyte development and lymphocyte populations are unaltered, and clonal deletion of potentially self-reactive T cells is not impaired. However, TNF signaling is largely abolished, as judged by the failure of TNF to induce NF-κB in T lymphocytes from TNFRp55-deficient The loss of TNFRp55 function renders mice resistant to lethal dosages of either lipopolysaccharides or S. aureus enterotoxin B. In contrast, TNFRp55-deficient mice are severely impaired to clear L. monocytogenes and readily succumb to infection. Thus, the 55 kd TNFR plays a decisive role in the host's defense against microorganisms and their pathogenic factors. © 1993.-
dc.languageeng-
dc.relation.ispartofCell-
dc.titleMice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/0092-8674(93)90134-C-
dc.identifier.pmid8387893-
dc.identifier.scopuseid_2-s2.0-0027297663-
dc.identifier.volume73-
dc.identifier.issue3-
dc.identifier.spage457-
dc.identifier.epage467-
dc.identifier.isiWOS:A1993LA74300008-
dc.identifier.issnl0092-8674-

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