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- Publisher Website: 10.1016/0952-7915(93)90010-P
- Scopus: eid_2-s2.0-0027156322
- PMID: 8507400
- WOS: WOS:A1993KY90900010
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Article: CD4, CD8 and tyrosine kinases in thymic selection
Title | CD4, CD8 and tyrosine kinases in thymic selection |
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Authors | |
Issue Date | 1993 |
Citation | Current Opinion in Immunology, 1993, v. 5, n. 2, p. 235-240 How to Cite? |
Abstract | Analysis of T-cell development in transgenic and gene-deficient mice suggests that the co-receptor function of CD8 is essential for positive selection. Recent data also demonstrate that the requirement for CD4 and CD8 in negative selection of T cells is not absolute and may be regulated by T-cell receptor affinity for the deleting ligand, an interpretation consistent with the affinity model of thymic selection. In addition to its association with CD4 and CD8, it appears that p56lck is also important during the early stages of thymic development. © 1993. |
Persistent Identifier | http://hdl.handle.net/10722/292403 |
ISSN | 2023 Impact Factor: 6.6 2023 SCImago Journal Rankings: 2.841 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Wallace, Valerie A. | - |
dc.contributor.author | Penninger, Josef | - |
dc.contributor.author | Mak, Tak W. | - |
dc.date.accessioned | 2020-11-17T14:56:25Z | - |
dc.date.available | 2020-11-17T14:56:25Z | - |
dc.date.issued | 1993 | - |
dc.identifier.citation | Current Opinion in Immunology, 1993, v. 5, n. 2, p. 235-240 | - |
dc.identifier.issn | 0952-7915 | - |
dc.identifier.uri | http://hdl.handle.net/10722/292403 | - |
dc.description.abstract | Analysis of T-cell development in transgenic and gene-deficient mice suggests that the co-receptor function of CD8 is essential for positive selection. Recent data also demonstrate that the requirement for CD4 and CD8 in negative selection of T cells is not absolute and may be regulated by T-cell receptor affinity for the deleting ligand, an interpretation consistent with the affinity model of thymic selection. In addition to its association with CD4 and CD8, it appears that p56lck is also important during the early stages of thymic development. © 1993. | - |
dc.language | eng | - |
dc.relation.ispartof | Current Opinion in Immunology | - |
dc.title | CD4, CD8 and tyrosine kinases in thymic selection | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/0952-7915(93)90010-P | - |
dc.identifier.pmid | 8507400 | - |
dc.identifier.scopus | eid_2-s2.0-0027156322 | - |
dc.identifier.volume | 5 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 235 | - |
dc.identifier.epage | 240 | - |
dc.identifier.isi | WOS:A1993KY90900010 | - |
dc.identifier.issnl | 0952-7915 | - |