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- Publisher Website: 10.1016/0092-8674(91)90462-8
- Scopus: eid_2-s2.0-0025906133
- PMID: 1673361
- WOS: WOS:A1991FK18200011
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Article: CD8 is needed for development of cytotoxic T but not helper T cells
Title | CD8 is needed for development of cytotoxic T but not helper T cells |
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Authors | |
Issue Date | 1991 |
Citation | Cell, 1991, v. 65, n. 3, p. 443-449 How to Cite? |
Abstract | A mutant mouse strain without CD8 (Lyt-2 and Lyt-3) expression on the cell surface has been generated by disrupting the Lyt-2 gene using embryonic stem cell technology. In these mice, CD8+T lymphocytes are not present in peripheral lymphoid organs, but the CD4+ T lymphocyte population seems to be unaltered. Cytotoxic response of T lymphocytes from these mice against alloantigens and viral antigens is dramatically decreased. Proliferative response against alloantigens and in vivo help to B lymphocytes, however, are not affected. These data suggest that CD8 is necessary for the maturation and positive selection of class I MHC restricted cytotoxic T lymphocytes but is not required on any of the intermediate thymocyte populations (CD8+CD4-TcR- or CD4+CD8+TcRlow) during the development of functional class II MHC restricted helper T cells. © 1991. |
Persistent Identifier | http://hdl.handle.net/10722/292384 |
ISSN | 2023 Impact Factor: 45.5 2023 SCImago Journal Rankings: 24.342 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Fung-Leung, Wai Ping | - |
dc.contributor.author | Schilham, Marco W. | - |
dc.contributor.author | Rahemtulla, Amin | - |
dc.contributor.author | Kündig, Thomas M. | - |
dc.contributor.author | Vollenweider, Maja | - |
dc.contributor.author | Potter, Julia | - |
dc.contributor.author | van Ewijk, Willem | - |
dc.contributor.author | Mak, Tak W. | - |
dc.date.accessioned | 2020-11-17T14:56:22Z | - |
dc.date.available | 2020-11-17T14:56:22Z | - |
dc.date.issued | 1991 | - |
dc.identifier.citation | Cell, 1991, v. 65, n. 3, p. 443-449 | - |
dc.identifier.issn | 0092-8674 | - |
dc.identifier.uri | http://hdl.handle.net/10722/292384 | - |
dc.description.abstract | A mutant mouse strain without CD8 (Lyt-2 and Lyt-3) expression on the cell surface has been generated by disrupting the Lyt-2 gene using embryonic stem cell technology. In these mice, CD8+T lymphocytes are not present in peripheral lymphoid organs, but the CD4+ T lymphocyte population seems to be unaltered. Cytotoxic response of T lymphocytes from these mice against alloantigens and viral antigens is dramatically decreased. Proliferative response against alloantigens and in vivo help to B lymphocytes, however, are not affected. These data suggest that CD8 is necessary for the maturation and positive selection of class I MHC restricted cytotoxic T lymphocytes but is not required on any of the intermediate thymocyte populations (CD8+CD4-TcR- or CD4+CD8+TcRlow) during the development of functional class II MHC restricted helper T cells. © 1991. | - |
dc.language | eng | - |
dc.relation.ispartof | Cell | - |
dc.title | CD8 is needed for development of cytotoxic T but not helper T cells | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/0092-8674(91)90462-8 | - |
dc.identifier.pmid | 1673361 | - |
dc.identifier.scopus | eid_2-s2.0-0025906133 | - |
dc.identifier.volume | 65 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 443 | - |
dc.identifier.epage | 449 | - |
dc.identifier.isi | WOS:A1991FK18200011 | - |
dc.identifier.issnl | 0092-8674 | - |