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Article: Immune response against lymphocytic choriomeningitis virus infection in mice without CD8 expression

TitleImmune response against lymphocytic choriomeningitis virus infection in mice without CD8 expression
Authors
Issue Date1991
Citation
Journal of Experimental Medicine, 1991, v. 174, n. 6, p. 1425-1429 How to Cite?
AbstractThe immune response against lymphocytic choriomeningitis virus (LCMV) was studied in a mutant mouse strain that does not possess CD8+ T lymphocytes. Virus-specific cytotoxic T cell activity was generated in spleens of wild-type mice in an acute LCMV infection but was not measurable in mutant mice. Injection of replicating LCMV into footpads of wild-type mice induced a CD8+ T cell-mediated swelling that peaked on day 8, followed by a CD4+ T cell-mediated swelling that peaked on day 11, whereas mutant mice exhibited only the CD4+ T cell-mediated swelling. After intracerebral inoculation with LCMV-Armstrong, all wild-type mice died of classical CD8+ T cell-dependent choriomeningitis in 8-10 days. Mutant mice showed symptoms of general malaise but most of them survived. Mutant mice depleted of CD4+ T cells by monoclonal antibody treatment showed no clinical signs of sickness. On day 9 after intravenous infection with LCMV-WE, virus was detected at high titers in spleens and livers of mutant mice but not in those of wild-type mice. On day 70 after injection of LCMV-WE into footpads, virus was not detected in wild-type mice and in one of the three mutant mice tested, but was still measurable in kidneys of the other two mutant mice. These results confirm in a new animal model that CD8+ T cell-mediated immunity is crucial in LCMV clearance and in the immunopathological disease during LCMV infection. In addition, our results demonstrated a less severe form of choriomeningitis mediated by CD4+ T cells and slow clearance of LCMV by alternative pathways independent of CD8+ T cells. © 1991, Rockefeller University Press., All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/292376
ISSN
2023 Impact Factor: 12.6
2023 SCImago Journal Rankings: 6.838
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorFung-Leung, Wai Ping-
dc.contributor.authorKündig, Thomas M.-
dc.contributor.authorZinkernagel, Rolf M.-
dc.contributor.authorMak, Tak W.-
dc.date.accessioned2020-11-17T14:56:20Z-
dc.date.available2020-11-17T14:56:20Z-
dc.date.issued1991-
dc.identifier.citationJournal of Experimental Medicine, 1991, v. 174, n. 6, p. 1425-1429-
dc.identifier.issn0022-1007-
dc.identifier.urihttp://hdl.handle.net/10722/292376-
dc.description.abstractThe immune response against lymphocytic choriomeningitis virus (LCMV) was studied in a mutant mouse strain that does not possess CD8+ T lymphocytes. Virus-specific cytotoxic T cell activity was generated in spleens of wild-type mice in an acute LCMV infection but was not measurable in mutant mice. Injection of replicating LCMV into footpads of wild-type mice induced a CD8+ T cell-mediated swelling that peaked on day 8, followed by a CD4+ T cell-mediated swelling that peaked on day 11, whereas mutant mice exhibited only the CD4+ T cell-mediated swelling. After intracerebral inoculation with LCMV-Armstrong, all wild-type mice died of classical CD8+ T cell-dependent choriomeningitis in 8-10 days. Mutant mice showed symptoms of general malaise but most of them survived. Mutant mice depleted of CD4+ T cells by monoclonal antibody treatment showed no clinical signs of sickness. On day 9 after intravenous infection with LCMV-WE, virus was detected at high titers in spleens and livers of mutant mice but not in those of wild-type mice. On day 70 after injection of LCMV-WE into footpads, virus was not detected in wild-type mice and in one of the three mutant mice tested, but was still measurable in kidneys of the other two mutant mice. These results confirm in a new animal model that CD8+ T cell-mediated immunity is crucial in LCMV clearance and in the immunopathological disease during LCMV infection. In addition, our results demonstrated a less severe form of choriomeningitis mediated by CD4+ T cells and slow clearance of LCMV by alternative pathways independent of CD8+ T cells. © 1991, Rockefeller University Press., All rights reserved.-
dc.languageeng-
dc.relation.ispartofJournal of Experimental Medicine-
dc.titleImmune response against lymphocytic choriomeningitis virus infection in mice without CD8 expression-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1084/jem.174.6.1425-
dc.identifier.pmid1683893-
dc.identifier.pmcidPMC2119037-
dc.identifier.scopuseid_2-s2.0-0025720569-
dc.identifier.volume174-
dc.identifier.issue6-
dc.identifier.spage1425-
dc.identifier.epage1429-
dc.identifier.eissn1540-9538-
dc.identifier.isiWOS:A1991GU64400015-
dc.identifier.issnl0022-1007-

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