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Article: Expression of the Human T-Cell-specific Tyrosine Kinase YT16 (lck) Message in Leukemic T-Cell Lines
Title | Expression of the Human T-Cell-specific Tyrosine Kinase YT16 (lck) Message in Leukemic T-Cell Lines |
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Authors | |
Issue Date | 1988 |
Citation | Cancer Research, 1988, v. 48, n. 4, p. 856-859 How to Cite? |
Abstract | To evaluate the role of the human T-cell-specific tyrosine kinase lck (YT16) we measured the levels of lck expression in thymocytes, peripheral T-cells, and leukemia T-cell lines which are arrested at different stages of thymic differentiation. The results indicate that higher levels of the lek message can be found in total thymocytes and T-cells arrested at Stage III (thymocytes that have rearranged their α, β, and γ chain T-cell receptor genes). A 20-fold lower level of these transcripts, however, can be found in cells derived from Stage I cells (thymocytes with germline α, β, and γ genes), 4 times less messages in Stage II cells (thymocytes with rearranged γ and β chain genes, but with germline α chain genes), and a 4-fold lower amount of RNA in Stage IV cells (mature lymphocytes). Culture of these cells with a variety of inducing reagents indicated that leukemia cell lines of only Stages I and II can be induced to increase their levels of YT16 expression by the addition of tetradecanoyl phorbol-13-acetate. These results suggest that there may be a developmental regulation of these tyrosine kinase messages during T-cell ontogeny. The high level of these transcripts in more mature T-cell leukemia lines suggests that they may primarily play a role in the proliferative controls of these cells. © 1988, American Association for Cancer Research. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/292339 |
ISSN | 2023 Impact Factor: 12.5 2023 SCImago Journal Rankings: 3.468 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Koga, Yasuhiro | - |
dc.contributor.author | Kimura, Nobuhiro | - |
dc.contributor.author | Minowada, Jun | - |
dc.contributor.author | Mak, Tak | - |
dc.date.accessioned | 2020-11-17T14:56:15Z | - |
dc.date.available | 2020-11-17T14:56:15Z | - |
dc.date.issued | 1988 | - |
dc.identifier.citation | Cancer Research, 1988, v. 48, n. 4, p. 856-859 | - |
dc.identifier.issn | 0008-5472 | - |
dc.identifier.uri | http://hdl.handle.net/10722/292339 | - |
dc.description.abstract | To evaluate the role of the human T-cell-specific tyrosine kinase lck (YT16) we measured the levels of lck expression in thymocytes, peripheral T-cells, and leukemia T-cell lines which are arrested at different stages of thymic differentiation. The results indicate that higher levels of the lek message can be found in total thymocytes and T-cells arrested at Stage III (thymocytes that have rearranged their α, β, and γ chain T-cell receptor genes). A 20-fold lower level of these transcripts, however, can be found in cells derived from Stage I cells (thymocytes with germline α, β, and γ genes), 4 times less messages in Stage II cells (thymocytes with rearranged γ and β chain genes, but with germline α chain genes), and a 4-fold lower amount of RNA in Stage IV cells (mature lymphocytes). Culture of these cells with a variety of inducing reagents indicated that leukemia cell lines of only Stages I and II can be induced to increase their levels of YT16 expression by the addition of tetradecanoyl phorbol-13-acetate. These results suggest that there may be a developmental regulation of these tyrosine kinase messages during T-cell ontogeny. The high level of these transcripts in more mature T-cell leukemia lines suggests that they may primarily play a role in the proliferative controls of these cells. © 1988, American Association for Cancer Research. All rights reserved. | - |
dc.language | eng | - |
dc.relation.ispartof | Cancer Research | - |
dc.title | Expression of the Human T-Cell-specific Tyrosine Kinase YT16 (lck) Message in Leukemic T-Cell Lines | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.pmid | 3257410 | - |
dc.identifier.scopus | eid_2-s2.0-0023911241 | - |
dc.identifier.volume | 48 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 856 | - |
dc.identifier.epage | 859 | - |
dc.identifier.eissn | 1538-7445 | - |
dc.identifier.isi | WOS:A1988M081500018 | - |
dc.identifier.issnl | 0008-5472 | - |