File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Expression of the Human T-Cell-specific Tyrosine Kinase YT16 (lck) Message in Leukemic T-Cell Lines

TitleExpression of the Human T-Cell-specific Tyrosine Kinase YT16 (lck) Message in Leukemic T-Cell Lines
Authors
Issue Date1988
Citation
Cancer Research, 1988, v. 48, n. 4, p. 856-859 How to Cite?
AbstractTo evaluate the role of the human T-cell-specific tyrosine kinase lck (YT16) we measured the levels of lck expression in thymocytes, peripheral T-cells, and leukemia T-cell lines which are arrested at different stages of thymic differentiation. The results indicate that higher levels of the lek message can be found in total thymocytes and T-cells arrested at Stage III (thymocytes that have rearranged their α, β, and γ chain T-cell receptor genes). A 20-fold lower level of these transcripts, however, can be found in cells derived from Stage I cells (thymocytes with germline α, β, and γ genes), 4 times less messages in Stage II cells (thymocytes with rearranged γ and β chain genes, but with germline α chain genes), and a 4-fold lower amount of RNA in Stage IV cells (mature lymphocytes). Culture of these cells with a variety of inducing reagents indicated that leukemia cell lines of only Stages I and II can be induced to increase their levels of YT16 expression by the addition of tetradecanoyl phorbol-13-acetate. These results suggest that there may be a developmental regulation of these tyrosine kinase messages during T-cell ontogeny. The high level of these transcripts in more mature T-cell leukemia lines suggests that they may primarily play a role in the proliferative controls of these cells. © 1988, American Association for Cancer Research. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/292339
ISSN
2023 Impact Factor: 12.5
2023 SCImago Journal Rankings: 3.468
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKoga, Yasuhiro-
dc.contributor.authorKimura, Nobuhiro-
dc.contributor.authorMinowada, Jun-
dc.contributor.authorMak, Tak-
dc.date.accessioned2020-11-17T14:56:15Z-
dc.date.available2020-11-17T14:56:15Z-
dc.date.issued1988-
dc.identifier.citationCancer Research, 1988, v. 48, n. 4, p. 856-859-
dc.identifier.issn0008-5472-
dc.identifier.urihttp://hdl.handle.net/10722/292339-
dc.description.abstractTo evaluate the role of the human T-cell-specific tyrosine kinase lck (YT16) we measured the levels of lck expression in thymocytes, peripheral T-cells, and leukemia T-cell lines which are arrested at different stages of thymic differentiation. The results indicate that higher levels of the lek message can be found in total thymocytes and T-cells arrested at Stage III (thymocytes that have rearranged their α, β, and γ chain T-cell receptor genes). A 20-fold lower level of these transcripts, however, can be found in cells derived from Stage I cells (thymocytes with germline α, β, and γ genes), 4 times less messages in Stage II cells (thymocytes with rearranged γ and β chain genes, but with germline α chain genes), and a 4-fold lower amount of RNA in Stage IV cells (mature lymphocytes). Culture of these cells with a variety of inducing reagents indicated that leukemia cell lines of only Stages I and II can be induced to increase their levels of YT16 expression by the addition of tetradecanoyl phorbol-13-acetate. These results suggest that there may be a developmental regulation of these tyrosine kinase messages during T-cell ontogeny. The high level of these transcripts in more mature T-cell leukemia lines suggests that they may primarily play a role in the proliferative controls of these cells. © 1988, American Association for Cancer Research. All rights reserved.-
dc.languageeng-
dc.relation.ispartofCancer Research-
dc.titleExpression of the Human T-Cell-specific Tyrosine Kinase YT16 (lck) Message in Leukemic T-Cell Lines-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.pmid3257410-
dc.identifier.scopuseid_2-s2.0-0023911241-
dc.identifier.volume48-
dc.identifier.issue4-
dc.identifier.spage856-
dc.identifier.epage859-
dc.identifier.eissn1538-7445-
dc.identifier.isiWOS:A1988M081500018-
dc.identifier.issnl0008-5472-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats