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- Publisher Website: 10.1002/eji.1830171121
- Scopus: eid_2-s2.0-0023510107
- PMID: 2960549
- WOS: WOS:A1987L391500020
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Article: Rearrangement and organization of T cell receptor gamma chain genes in human leukemic T cell lines
Title | Rearrangement and organization of T cell receptor gamma chain genes in human leukemic T cell lines |
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Authors | |
Issue Date | 1987 |
Citation | European Journal of Immunology, 1987, v. 17, n. 11, p. 1653-1656 How to Cite? |
Abstract | Seventeen T cell leukemic lines, which are arrested at different stages of differentiation, were analyzed for γ‐chain rearrangement and expression using the constant region gene and representatives of the different families of Vγ chain genes. With the exception of the T cell line P30/OKUBO, which is arrested at the earliest stage (stage I), all the leukemic lines have rearranged their γ‐chain genes and transcripts can be detected in all but MOLT‐4 and P30/OKUBO cell lines. Although Vγ1 genes were rearranged and expressed in leukemic lines arrested at stages II, III and IV, Vγ2 and Vγ3 were only rearranged and expressed in cells at stage III (0/5 in stage II, 5/9 in stage III and 0/1 in stage 4). Thus, there may be a sequential usage of Vγ gene during human T cell ontogeny (although it is possible that this may just be a coincidence), similar to that which has been shown during murine ontogeny. Based on the rearrangement data, the genomic order of 5′ Vγ1‐Vγ2‐Vγ3‐J‐C 3′ is proposed. Copyright © 1987 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim |
Persistent Identifier | http://hdl.handle.net/10722/292326 |
ISSN | 2023 Impact Factor: 4.5 2023 SCImago Journal Rankings: 1.627 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Kimura, Nobuhiro | - |
dc.contributor.author | Du, Ran‐Pan ‐P | - |
dc.contributor.author | Mak, Tak W. | - |
dc.date.accessioned | 2020-11-17T14:56:14Z | - |
dc.date.available | 2020-11-17T14:56:14Z | - |
dc.date.issued | 1987 | - |
dc.identifier.citation | European Journal of Immunology, 1987, v. 17, n. 11, p. 1653-1656 | - |
dc.identifier.issn | 0014-2980 | - |
dc.identifier.uri | http://hdl.handle.net/10722/292326 | - |
dc.description.abstract | Seventeen T cell leukemic lines, which are arrested at different stages of differentiation, were analyzed for γ‐chain rearrangement and expression using the constant region gene and representatives of the different families of Vγ chain genes. With the exception of the T cell line P30/OKUBO, which is arrested at the earliest stage (stage I), all the leukemic lines have rearranged their γ‐chain genes and transcripts can be detected in all but MOLT‐4 and P30/OKUBO cell lines. Although Vγ1 genes were rearranged and expressed in leukemic lines arrested at stages II, III and IV, Vγ2 and Vγ3 were only rearranged and expressed in cells at stage III (0/5 in stage II, 5/9 in stage III and 0/1 in stage 4). Thus, there may be a sequential usage of Vγ gene during human T cell ontogeny (although it is possible that this may just be a coincidence), similar to that which has been shown during murine ontogeny. Based on the rearrangement data, the genomic order of 5′ Vγ1‐Vγ2‐Vγ3‐J‐C 3′ is proposed. Copyright © 1987 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim | - |
dc.language | eng | - |
dc.relation.ispartof | European Journal of Immunology | - |
dc.title | Rearrangement and organization of T cell receptor gamma chain genes in human leukemic T cell lines | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1002/eji.1830171121 | - |
dc.identifier.pmid | 2960549 | - |
dc.identifier.scopus | eid_2-s2.0-0023510107 | - |
dc.identifier.volume | 17 | - |
dc.identifier.issue | 11 | - |
dc.identifier.spage | 1653 | - |
dc.identifier.epage | 1656 | - |
dc.identifier.eissn | 1521-4141 | - |
dc.identifier.isi | WOS:A1987L391500020 | - |
dc.identifier.issnl | 0014-2980 | - |