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- Publisher Website: 10.1016/0092-8674(86)90695-1
- Scopus: eid_2-s2.0-0023026643
- PMID: 3093081
- WOS: WOS:A1986E242100002
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Article: Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency
Title | Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency |
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Authors | |
Issue Date | 1986 |
Citation | Cell, 1986, v. 46, n. 7, p. 963-972 How to Cite? |
Abstract | A process unique to lymphocyte differentiation is the rearrangement of genes encoding antigen-specific receptors on B and T cells. A mouse mutant (C.B-17scid) with severe combined immune deficiency, i.e., that lacks functional B and T cells, shows no evidence of such gene rearrangements. However, rearrangements were detected in Abelson murine leukemia virus-transformed bone marrow cells and in spontaneous thymic lymphomas from C.B-17scid mice. Most of these rearrangements were abnormal: ∼80% of Igh rearrangements deleted the entire Jh region, and ∼60% of TCRβ rearrangements deleted the entire Jβ2 region. The deletions appeared to result from faulty D-to-J recombination. No such abnormal rearrangements were detected in transformed tissues from control mice. The scid mutation may adversely affect the recombinase system catalyzing the assembly of antigen receptor genes in developing B and T lymphocytes. © 1986. |
Persistent Identifier | http://hdl.handle.net/10722/292315 |
ISSN | 2023 Impact Factor: 45.5 2023 SCImago Journal Rankings: 24.342 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Schuler, Walter | - |
dc.contributor.author | Weiler, Ivan Jeanne | - |
dc.contributor.author | Schuler, Amelie | - |
dc.contributor.author | Phillips, Robert A. | - |
dc.contributor.author | Rosenberg, Naomi | - |
dc.contributor.author | Mak, Tak W. | - |
dc.contributor.author | Kearney, John F. | - |
dc.contributor.author | Perry, Robert P. | - |
dc.contributor.author | Bosma, Melvin J. | - |
dc.date.accessioned | 2020-11-17T14:56:12Z | - |
dc.date.available | 2020-11-17T14:56:12Z | - |
dc.date.issued | 1986 | - |
dc.identifier.citation | Cell, 1986, v. 46, n. 7, p. 963-972 | - |
dc.identifier.issn | 0092-8674 | - |
dc.identifier.uri | http://hdl.handle.net/10722/292315 | - |
dc.description.abstract | A process unique to lymphocyte differentiation is the rearrangement of genes encoding antigen-specific receptors on B and T cells. A mouse mutant (C.B-17scid) with severe combined immune deficiency, i.e., that lacks functional B and T cells, shows no evidence of such gene rearrangements. However, rearrangements were detected in Abelson murine leukemia virus-transformed bone marrow cells and in spontaneous thymic lymphomas from C.B-17scid mice. Most of these rearrangements were abnormal: ∼80% of Igh rearrangements deleted the entire Jh region, and ∼60% of TCRβ rearrangements deleted the entire Jβ2 region. The deletions appeared to result from faulty D-to-J recombination. No such abnormal rearrangements were detected in transformed tissues from control mice. The scid mutation may adversely affect the recombinase system catalyzing the assembly of antigen receptor genes in developing B and T lymphocytes. © 1986. | - |
dc.language | eng | - |
dc.relation.ispartof | Cell | - |
dc.title | Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/0092-8674(86)90695-1 | - |
dc.identifier.pmid | 3093081 | - |
dc.identifier.scopus | eid_2-s2.0-0023026643 | - |
dc.identifier.volume | 46 | - |
dc.identifier.issue | 7 | - |
dc.identifier.spage | 963 | - |
dc.identifier.epage | 972 | - |
dc.identifier.isi | WOS:A1986E242100002 | - |
dc.identifier.issnl | 0092-8674 | - |