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- Publisher Website: 10.1038/324482a0
- Scopus: eid_2-s2.0-0023008486
- PMID: 3785427
- WOS: WOS:A1986F087400069
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Article: Athymic mice express a high level of functional γ-chain but greatly reduced levels of α- and β-chain T-cell receptor messages
Title | Athymic mice express a high level of functional γ-chain but greatly reduced levels of α- and β-chain T-cell receptor messages |
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Authors | |
Issue Date | 1986 |
Citation | Nature, 1986, v. 324, n. 6096, p. 482-485 How to Cite? |
Abstract | T lymphocytes differentiate and mature in the thymus. It is here that thymocytes with reactivities to self antigens are eliminated and those with specificities to 'altered' self-major histocompatibility complex (MHC) gene products are positively selected1. The selections are presumably carried out on the basis of their T-cell antigen receptors (TcR). The genes of the α- and β-chain T-cell antigen receptors have been cloned 2-7. A third T-cell specific gene capable of undergoing somatic rearrangement has also been identified8; the role of this third gene is not known. An order of expression of γ, β, then α is found during T-cell ontogeny9,10. But although α- and β-chain messages are often functional11-15, γ transcripts are rarely functional in thymocytes or mature T cells16-18. To define the sequential order of expression of these genes further and to continue the search for a possible role for the TcR γ gene products, we investigated the expression of 'functional' α-, β- and γ-chain transcripts in young athymic mice. These mice express an undetectable amount (less than one in 8 × l05 spleen messages) of 'full-length' α- and β-chain T-cell receptor transcripts, but an increased level of expression of 'full-length' γ chain messages. Nucleotide sequence analysis of four γ complementary DNAs show that all four γ transcripts sequenced are functional. These findings suggest that γ gene products may be important in a prethymic or extrathymic pathway and may represent a second type of T-cell recognition, possibly in a lineage in which α and β genes are not used. © 1986 Nature Publishing Group. |
Persistent Identifier | http://hdl.handle.net/10722/292314 |
ISSN | 2023 Impact Factor: 50.5 2023 SCImago Journal Rankings: 18.509 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Yoshikai, Yasunobu | - |
dc.contributor.author | Reis, Marciano D. | - |
dc.contributor.author | Mak, Tak W. | - |
dc.date.accessioned | 2020-11-17T14:56:12Z | - |
dc.date.available | 2020-11-17T14:56:12Z | - |
dc.date.issued | 1986 | - |
dc.identifier.citation | Nature, 1986, v. 324, n. 6096, p. 482-485 | - |
dc.identifier.issn | 0028-0836 | - |
dc.identifier.uri | http://hdl.handle.net/10722/292314 | - |
dc.description.abstract | T lymphocytes differentiate and mature in the thymus. It is here that thymocytes with reactivities to self antigens are eliminated and those with specificities to 'altered' self-major histocompatibility complex (MHC) gene products are positively selected1. The selections are presumably carried out on the basis of their T-cell antigen receptors (TcR). The genes of the α- and β-chain T-cell antigen receptors have been cloned 2-7. A third T-cell specific gene capable of undergoing somatic rearrangement has also been identified8; the role of this third gene is not known. An order of expression of γ, β, then α is found during T-cell ontogeny9,10. But although α- and β-chain messages are often functional11-15, γ transcripts are rarely functional in thymocytes or mature T cells16-18. To define the sequential order of expression of these genes further and to continue the search for a possible role for the TcR γ gene products, we investigated the expression of 'functional' α-, β- and γ-chain transcripts in young athymic mice. These mice express an undetectable amount (less than one in 8 × l05 spleen messages) of 'full-length' α- and β-chain T-cell receptor transcripts, but an increased level of expression of 'full-length' γ chain messages. Nucleotide sequence analysis of four γ complementary DNAs show that all four γ transcripts sequenced are functional. These findings suggest that γ gene products may be important in a prethymic or extrathymic pathway and may represent a second type of T-cell recognition, possibly in a lineage in which α and β genes are not used. © 1986 Nature Publishing Group. | - |
dc.language | eng | - |
dc.relation.ispartof | Nature | - |
dc.title | Athymic mice express a high level of functional γ-chain but greatly reduced levels of α- and β-chain T-cell receptor messages | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1038/324482a0 | - |
dc.identifier.pmid | 3785427 | - |
dc.identifier.scopus | eid_2-s2.0-0023008486 | - |
dc.identifier.volume | 324 | - |
dc.identifier.issue | 6096 | - |
dc.identifier.spage | 482 | - |
dc.identifier.epage | 485 | - |
dc.identifier.isi | WOS:A1986F087400069 | - |
dc.identifier.issnl | 0028-0836 | - |