File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1016/j.tips.2010.05.003
- Scopus: eid_2-s2.0-77955280009
- PMID: 20561689
- WOS: WOS:000281176700003
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Fighting cancers from within: Augmenting tumor immunity with cytokine therapy
Title | Fighting cancers from within: Augmenting tumor immunity with cytokine therapy |
---|---|
Authors | |
Issue Date | 2010 |
Citation | Trends in Pharmacological Sciences, 2010, v. 31, n. 8, p. 356-363 How to Cite? |
Abstract | The human immune system has successfully evolved to fight many pathogens. Through vaccination, we can harness and improve immune responses to eradicate infections. Despite this success, we are only now beginning to understand the natural tumor immune surveillance mechanisms and why, in some instances, our immune system fails to abrogate the development and growth of tumors. Encouraging results with the latest immunotherapies have renewed enthusiasm in the field. A central component of these therapies is the contribution of cytokines. Here we review our expanding knowledge of cytokine-induced effects as well as preclinical and clinical data that indicate adjuvant cytokine therapies may hold much promise in improving anti-tumor immunity. Further studies on optimal synergistic combinations, timing, duration and additional adjuvant therapies are required to realize the full potential of cytokines as immunotherapeutic agents. © 2010 Elsevier Ltd. |
Persistent Identifier | http://hdl.handle.net/10722/292205 |
ISSN | 2023 Impact Factor: 13.9 2023 SCImago Journal Rankings: 3.232 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Pellegrini, Marc | - |
dc.contributor.author | Mak, Tak W. | - |
dc.contributor.author | Ohashi, Pamela S. | - |
dc.date.accessioned | 2020-11-17T14:55:59Z | - |
dc.date.available | 2020-11-17T14:55:59Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | Trends in Pharmacological Sciences, 2010, v. 31, n. 8, p. 356-363 | - |
dc.identifier.issn | 0165-6147 | - |
dc.identifier.uri | http://hdl.handle.net/10722/292205 | - |
dc.description.abstract | The human immune system has successfully evolved to fight many pathogens. Through vaccination, we can harness and improve immune responses to eradicate infections. Despite this success, we are only now beginning to understand the natural tumor immune surveillance mechanisms and why, in some instances, our immune system fails to abrogate the development and growth of tumors. Encouraging results with the latest immunotherapies have renewed enthusiasm in the field. A central component of these therapies is the contribution of cytokines. Here we review our expanding knowledge of cytokine-induced effects as well as preclinical and clinical data that indicate adjuvant cytokine therapies may hold much promise in improving anti-tumor immunity. Further studies on optimal synergistic combinations, timing, duration and additional adjuvant therapies are required to realize the full potential of cytokines as immunotherapeutic agents. © 2010 Elsevier Ltd. | - |
dc.language | eng | - |
dc.relation.ispartof | Trends in Pharmacological Sciences | - |
dc.title | Fighting cancers from within: Augmenting tumor immunity with cytokine therapy | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.tips.2010.05.003 | - |
dc.identifier.pmid | 20561689 | - |
dc.identifier.scopus | eid_2-s2.0-77955280009 | - |
dc.identifier.volume | 31 | - |
dc.identifier.issue | 8 | - |
dc.identifier.spage | 356 | - |
dc.identifier.epage | 363 | - |
dc.identifier.isi | WOS:000281176700003 | - |
dc.identifier.issnl | 0165-6147 | - |