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Article: Critical Roles of TRAF2 and TRAF5 in Tumor Necrosis Factor-induced NF-κB Activation and Protection from Cell Death

TitleCritical Roles of TRAF2 and TRAF5 in Tumor Necrosis Factor-induced NF-κB Activation and Protection from Cell Death
Authors
Issue Date2001
Citation
Journal of Biological Chemistry, 2001, v. 276, n. 39, p. 36530-36534 How to Cite?
AbstractTumor necrosis factor (TNF) receptor-associated factors (TRAFs) were identified as signal transducers for the TNF receptor superfamily. However, the exact roles of TRAF2 and TRAF5 in TNF-induced NF-κB activation still remain controversial. To address this issue, we generated TRAF2 and TRAF5 double knockout (DKO) mice. TNF- but not interleukin-1-induced nuclear translocation of NF-κB was severely impaired in murine embryonic fibroblasts (MEFs) derived from DKO mice. Moreover, DKO MEFs were more susceptible to TNF-induced cytotoxicity than TRAF2 knockout MEFs. Collectively, these results indicate that both TRAF2 and TRAF5 are involved in TNF-induced NF-κB activation and protection from cell death.
Persistent Identifierhttp://hdl.handle.net/10722/292183
ISSN
2019 Impact Factor: 4.238
2015 SCImago Journal Rankings: 3.151
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTada, Kurisu-
dc.contributor.authorOkazaki, Tatsuma-
dc.contributor.authorSakon, Sachiko-
dc.contributor.authorKobarai, Tomonari-
dc.contributor.authorKurosawa, Kyoko-
dc.contributor.authorYamaoka, Shoji-
dc.contributor.authorHashimoto, Hiroshi-
dc.contributor.authorMak, Tak Wah-
dc.contributor.authorYagita, Hideo-
dc.contributor.authorOkumura, Ko-
dc.contributor.authorYeh, Wen Chen-
dc.contributor.authorNakano, Hiroyasu-
dc.date.accessioned2020-11-17T14:55:56Z-
dc.date.available2020-11-17T14:55:56Z-
dc.date.issued2001-
dc.identifier.citationJournal of Biological Chemistry, 2001, v. 276, n. 39, p. 36530-36534-
dc.identifier.issn0021-9258-
dc.identifier.urihttp://hdl.handle.net/10722/292183-
dc.description.abstractTumor necrosis factor (TNF) receptor-associated factors (TRAFs) were identified as signal transducers for the TNF receptor superfamily. However, the exact roles of TRAF2 and TRAF5 in TNF-induced NF-κB activation still remain controversial. To address this issue, we generated TRAF2 and TRAF5 double knockout (DKO) mice. TNF- but not interleukin-1-induced nuclear translocation of NF-κB was severely impaired in murine embryonic fibroblasts (MEFs) derived from DKO mice. Moreover, DKO MEFs were more susceptible to TNF-induced cytotoxicity than TRAF2 knockout MEFs. Collectively, these results indicate that both TRAF2 and TRAF5 are involved in TNF-induced NF-κB activation and protection from cell death.-
dc.languageeng-
dc.relation.ispartofJournal of Biological Chemistry-
dc.titleCritical Roles of TRAF2 and TRAF5 in Tumor Necrosis Factor-induced NF-κB Activation and Protection from Cell Death-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1074/jbc.M104837200-
dc.identifier.pmid11479302-
dc.identifier.scopuseid_2-s2.0-0035965232-
dc.identifier.volume276-
dc.identifier.issue39-
dc.identifier.spage36530-
dc.identifier.epage36534-
dc.identifier.isiWOS:000171194500065-
dc.identifier.issnl0021-9258-

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