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- Publisher Website: 10.1002/(SICI)1521-4141(199907)29:07<2156::AID-IMMU2156>3.0.CO;2-P
- Scopus: eid_2-s2.0-0033038791
- PMID: 10427978
- WOS: WOS:000081369500012
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Article: Absence of co-stimulation and not the intensity of TCR signaling is critical for the induction of T cell unresponsiveness in vivo
Title | Absence of co-stimulation and not the intensity of TCR signaling is critical for the induction of T cell unresponsiveness in vivo |
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Authors | |
Keywords | Memory Altered peptide ligand Tolerance Vacciniation |
Issue Date | 1999 |
Citation | European Journal of Immunology, 1999, v. 29, n. 7, p. 2156-2166 How to Cite? |
Abstract | Understanding the mechanisms of T cell activation versus induction of unresponsiveness is of critical importance for the rational modulation of immune responses. Efficient T cell activation is critical for vaccination purposes, while the inhibition of T cell responses is potentially important for the ablation of autoimmune diseases. Modulation of co-stimulation and changing TCR-mediated signaling using altered peptide ligands (APL) have been shown to result in clonal T cell unresponsiveness. This study compares for the first time the efficiency of the two approaches for the induction of CD8+ T cell unresponsiveness in vivo for naive and memory T cells using TCR-transgenic mice. The results demonstrate that inhibition of CD28-mediated co-stimulation in the presence of a strong TCR-mediated signal most efficiently induces T cell unresponsiveness. In contrast, APL that are capable of weak TCR triggering fail to interfere with T cell responsiveness in vivo and are ignored by T cells. Thus, short-term blockage of CD28 during antigenic stimulation rather than the use of APL is the most promising way to actively down-modulate responsiveness of naive CD8+ T cells at least in the particular TCR-transgenic mouse model analyzed in this study. |
Persistent Identifier | http://hdl.handle.net/10722/292178 |
ISSN | 2023 Impact Factor: 4.5 2023 SCImago Journal Rankings: 1.627 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Bachmann, Martin F. | - |
dc.contributor.author | Speiser, Daniel E. | - |
dc.contributor.author | Mak, Tak W. | - |
dc.contributor.author | Ohashi, Pamela S. | - |
dc.date.accessioned | 2020-11-17T14:55:55Z | - |
dc.date.available | 2020-11-17T14:55:55Z | - |
dc.date.issued | 1999 | - |
dc.identifier.citation | European Journal of Immunology, 1999, v. 29, n. 7, p. 2156-2166 | - |
dc.identifier.issn | 0014-2980 | - |
dc.identifier.uri | http://hdl.handle.net/10722/292178 | - |
dc.description.abstract | Understanding the mechanisms of T cell activation versus induction of unresponsiveness is of critical importance for the rational modulation of immune responses. Efficient T cell activation is critical for vaccination purposes, while the inhibition of T cell responses is potentially important for the ablation of autoimmune diseases. Modulation of co-stimulation and changing TCR-mediated signaling using altered peptide ligands (APL) have been shown to result in clonal T cell unresponsiveness. This study compares for the first time the efficiency of the two approaches for the induction of CD8+ T cell unresponsiveness in vivo for naive and memory T cells using TCR-transgenic mice. The results demonstrate that inhibition of CD28-mediated co-stimulation in the presence of a strong TCR-mediated signal most efficiently induces T cell unresponsiveness. In contrast, APL that are capable of weak TCR triggering fail to interfere with T cell responsiveness in vivo and are ignored by T cells. Thus, short-term blockage of CD28 during antigenic stimulation rather than the use of APL is the most promising way to actively down-modulate responsiveness of naive CD8+ T cells at least in the particular TCR-transgenic mouse model analyzed in this study. | - |
dc.language | eng | - |
dc.relation.ispartof | European Journal of Immunology | - |
dc.subject | Memory | - |
dc.subject | Altered peptide ligand | - |
dc.subject | Tolerance | - |
dc.subject | Vacciniation | - |
dc.title | Absence of co-stimulation and not the intensity of TCR signaling is critical for the induction of T cell unresponsiveness in vivo | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1002/(SICI)1521-4141(199907)29:07<2156::AID-IMMU2156>3.0.CO;2-P | - |
dc.identifier.pmid | 10427978 | - |
dc.identifier.scopus | eid_2-s2.0-0033038791 | - |
dc.identifier.volume | 29 | - |
dc.identifier.issue | 7 | - |
dc.identifier.spage | 2156 | - |
dc.identifier.epage | 2166 | - |
dc.identifier.isi | WOS:000081369500012 | - |
dc.identifier.issnl | 0014-2980 | - |