File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Acute graft-versus-host disease without costimulation via CD28

TitleAcute graft-versus-host disease without costimulation via CD28
Authors
Issue Date1997
Citation
Transplantation, 1997, v. 63, n. 7, p. 1042-1044 How to Cite?
AbstractT lymphocyte activity is enhanced by costimulatory signals mediated through CD28 binding to B7-1/B7-2 on antigen-presenting cells. Several recent studies have shown that graft-versus-host disease (GVHD) can be inhibited by in vivo treatment with CTLA4Ig, which blocks CD28-B7 interactions. These findings prompted us to investigate the role of CD28 in acute GVHD, using gene-targeted mice. We performed the experiments in the context of strong allogeneic MHC stimulation (H2b anti-H2(d)) and weak stimulation (H2(d) anti-H2b). In both directions, efficient in vitro T-cell cytotoxicity and acute lethal GVHD were induced by CD28-deficient lymphocytes, which was only partially delayed when compared with wild-type mice. We conclude that lethal GVHD can develop without costimulation via CD28.
Persistent Identifierhttp://hdl.handle.net/10722/292174
ISSN
2023 Impact Factor: 5.3
2023 SCImago Journal Rankings: 1.371
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSpeiser, Daniel E.-
dc.contributor.authorBachmann, Martin F.-
dc.contributor.authorShahinian, Arda-
dc.contributor.authorMak, Tak W.-
dc.contributor.authorOhashi, Pamela S.-
dc.date.accessioned2020-11-17T14:55:55Z-
dc.date.available2020-11-17T14:55:55Z-
dc.date.issued1997-
dc.identifier.citationTransplantation, 1997, v. 63, n. 7, p. 1042-1044-
dc.identifier.issn0041-1337-
dc.identifier.urihttp://hdl.handle.net/10722/292174-
dc.description.abstractT lymphocyte activity is enhanced by costimulatory signals mediated through CD28 binding to B7-1/B7-2 on antigen-presenting cells. Several recent studies have shown that graft-versus-host disease (GVHD) can be inhibited by in vivo treatment with CTLA4Ig, which blocks CD28-B7 interactions. These findings prompted us to investigate the role of CD28 in acute GVHD, using gene-targeted mice. We performed the experiments in the context of strong allogeneic MHC stimulation (H2b anti-H2(d)) and weak stimulation (H2(d) anti-H2b). In both directions, efficient in vitro T-cell cytotoxicity and acute lethal GVHD were induced by CD28-deficient lymphocytes, which was only partially delayed when compared with wild-type mice. We conclude that lethal GVHD can develop without costimulation via CD28.-
dc.languageeng-
dc.relation.ispartofTransplantation-
dc.titleAcute graft-versus-host disease without costimulation via CD28-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/00007890-199704150-00028-
dc.identifier.pmid9112366-
dc.identifier.scopuseid_2-s2.0-0031002123-
dc.identifier.volume63-
dc.identifier.issue7-
dc.identifier.spage1042-
dc.identifier.epage1044-
dc.identifier.isiWOS:A1997WU37500028-
dc.identifier.issnl0041-1337-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats