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Article: The remediation effects of working memory training in schizophrenia patients with prominent negative symptoms

TitleThe remediation effects of working memory training in schizophrenia patients with prominent negative symptoms
Authors
KeywordsDual n-back training
hedonic processing
functional magnetic resonance imaging (fMRI)
anticipatory pleasure
consummatory pleasure
Issue Date2019
Citation
Cognitive Neuropsychiatry, 2019, v. 24, n. 6, p. 434-453 How to Cite?
Abstract© 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group. Introduction: Negative symptoms, particularly amotivation and anhedonia, are important predictors of poor functional outcome in patients with schizophrenia. There has been interest in the efficacy and mechanism of non-pharmacological interventions to alleviate these symptoms. The present study aimed to examine the remediation effect of working memory (WM) training in patients with schizophrenia with prominent negative symptoms. Methods: Thirty-one schizophrenia patients with prominent negative symptoms were recruited and assigned to either a WM training group or a treatment-as-usual (TAU) control group. The WM training group underwent 20 sessions of training using the dual n-back task over one month. A functional neuroimaging paradigm of the Affective Incentive Delay (AID) task was administered before and after the training intervention to evaluate the remediation effect of the intervention. Results: Our results showed that the WM training group demonstrated significant improvement in the WM training task and inattention symptoms. Compared with the TAU group, increased brain activations were observed at the right insula and the right frontal sub-gyral after WM training in the training group. Conclusions: These findings support the efficacy of WM training in ameliorating hedonic dysfunction in schizophrenia patients with prominent negative symptoms.
Persistent Identifierhttp://hdl.handle.net/10722/292128
ISSN
2023 Impact Factor: 1.5
2023 SCImago Journal Rankings: 0.680
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, Xu-
dc.contributor.authorChu, Min Yi-
dc.contributor.authorLv, Qin Yu-
dc.contributor.authorHu, Hui Xin-
dc.contributor.authorLi, Zhi-
dc.contributor.authorYi, Zheng Hui-
dc.contributor.authorWang, Jin Hong-
dc.contributor.authorZhang, Jian Ye-
dc.contributor.authorLui, Simon S.Y.-
dc.contributor.authorCheung, Eric F.C.-
dc.contributor.authorShum, David H.K.-
dc.contributor.authorChan, Raymond C.K.-
dc.date.accessioned2020-11-17T14:55:49Z-
dc.date.available2020-11-17T14:55:49Z-
dc.date.issued2019-
dc.identifier.citationCognitive Neuropsychiatry, 2019, v. 24, n. 6, p. 434-453-
dc.identifier.issn1354-6805-
dc.identifier.urihttp://hdl.handle.net/10722/292128-
dc.description.abstract© 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group. Introduction: Negative symptoms, particularly amotivation and anhedonia, are important predictors of poor functional outcome in patients with schizophrenia. There has been interest in the efficacy and mechanism of non-pharmacological interventions to alleviate these symptoms. The present study aimed to examine the remediation effect of working memory (WM) training in patients with schizophrenia with prominent negative symptoms. Methods: Thirty-one schizophrenia patients with prominent negative symptoms were recruited and assigned to either a WM training group or a treatment-as-usual (TAU) control group. The WM training group underwent 20 sessions of training using the dual n-back task over one month. A functional neuroimaging paradigm of the Affective Incentive Delay (AID) task was administered before and after the training intervention to evaluate the remediation effect of the intervention. Results: Our results showed that the WM training group demonstrated significant improvement in the WM training task and inattention symptoms. Compared with the TAU group, increased brain activations were observed at the right insula and the right frontal sub-gyral after WM training in the training group. Conclusions: These findings support the efficacy of WM training in ameliorating hedonic dysfunction in schizophrenia patients with prominent negative symptoms.-
dc.languageeng-
dc.relation.ispartofCognitive Neuropsychiatry-
dc.subjectDual n-back training-
dc.subjecthedonic processing-
dc.subjectfunctional magnetic resonance imaging (fMRI)-
dc.subjectanticipatory pleasure-
dc.subjectconsummatory pleasure-
dc.titleThe remediation effects of working memory training in schizophrenia patients with prominent negative symptoms-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1080/13546805.2019.1674644-
dc.identifier.pmid31583951-
dc.identifier.scopuseid_2-s2.0-85074039597-
dc.identifier.hkuros319895-
dc.identifier.volume24-
dc.identifier.issue6-
dc.identifier.spage434-
dc.identifier.epage453-
dc.identifier.eissn1464-0619-
dc.identifier.isiWOS:000498464100001-
dc.identifier.issnl1354-6805-

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