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- Publisher Website: 10.1007/s12185-016-1973-7
- Scopus: eid_2-s2.0-84961195653
- PMID: 26980223
- WOS: WOS:000377801400004
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Article: Roles of IDH1/2 and TET2 mutations in myeloid disorders
Title | Roles of IDH1/2 and TET2 mutations in myeloid disorders |
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Authors | |
Keywords | DNA damage DNA repair IDH1 TET2 AML MDS |
Issue Date | 2016 |
Citation | International Journal of Hematology, 2016, v. 103, n. 6, p. 627-633 How to Cite? |
Abstract | © 2016, The Japanese Society of Hematology. Mutations of the epigenetic enzymes isocitrate dehydrogenase (IDH) 1 and 2, and the methylcytosine dioxygenase ‘ten–eleven translocation 2’ (TET2), are common in human myeloid malignancies and drivers of these disorders but the underlying mechanisms remain obscure. This review examines mutant IDH1/2 and TET2 enzymes in the context of responses to DNA damage and their potential involvement in age-related genomic instability. The clinical relevance of these findings and their potential application in novel therapeutic strategies is also discussed. |
Persistent Identifier | http://hdl.handle.net/10722/292068 |
ISSN | 2023 Impact Factor: 1.7 2023 SCImago Journal Rankings: 0.594 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Inoue, Satoshi | - |
dc.contributor.author | Lemonnier, François | - |
dc.contributor.author | Mak, Tak W. | - |
dc.date.accessioned | 2020-11-17T14:55:42Z | - |
dc.date.available | 2020-11-17T14:55:42Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | International Journal of Hematology, 2016, v. 103, n. 6, p. 627-633 | - |
dc.identifier.issn | 0925-5710 | - |
dc.identifier.uri | http://hdl.handle.net/10722/292068 | - |
dc.description.abstract | © 2016, The Japanese Society of Hematology. Mutations of the epigenetic enzymes isocitrate dehydrogenase (IDH) 1 and 2, and the methylcytosine dioxygenase ‘ten–eleven translocation 2’ (TET2), are common in human myeloid malignancies and drivers of these disorders but the underlying mechanisms remain obscure. This review examines mutant IDH1/2 and TET2 enzymes in the context of responses to DNA damage and their potential involvement in age-related genomic instability. The clinical relevance of these findings and their potential application in novel therapeutic strategies is also discussed. | - |
dc.language | eng | - |
dc.relation.ispartof | International Journal of Hematology | - |
dc.subject | DNA damage | - |
dc.subject | DNA repair | - |
dc.subject | IDH1 | - |
dc.subject | TET2 | - |
dc.subject | AML | - |
dc.subject | MDS | - |
dc.title | Roles of IDH1/2 and TET2 mutations in myeloid disorders | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1007/s12185-016-1973-7 | - |
dc.identifier.pmid | 26980223 | - |
dc.identifier.scopus | eid_2-s2.0-84961195653 | - |
dc.identifier.volume | 103 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 627 | - |
dc.identifier.epage | 633 | - |
dc.identifier.eissn | 1865-3774 | - |
dc.identifier.isi | WOS:000377801400004 | - |
dc.identifier.issnl | 0925-5710 | - |