File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: IL-17A secretion by CD8+ T cells supports Th17-mediated autoimmune encephalomyelitis

TitleIL-17A secretion by CD8<sup>+</sup> T cells supports Th17-mediated autoimmune encephalomyelitis
Authors
Issue Date2013
Citation
Journal of Clinical Investigation, 2013, v. 123, n. 1, p. 247-260 How to Cite?
AbstractIL-17-producing CD8+ T (Tc17) cells are detectible in multiple sclerosis (MS) lesions; however, their contribution to the disease is unknown. To identify functions of Tc17 cells, we induced EAE, a murine model of MS, in mice lacking IFN regulatory factor 4 (IRF4). IRF4-deficient mice failed to generate Tc17 and Th17 cells and were resistant to EAE. After adoptive transfer of WT CD8+ T cells and subsequent immunization for EAE induction in these mice, the CD8+ T cells developed a Tc17 phenotype in the periphery but could not infiltrate the CNS. Similarly, transfer of small numbers of WT CD4+ T cells alone did not evoke EAE, but when transferred together with CD8+ T cells, IL-17-producing CD4+ (Th17) T cells accumulated in the CNS and mice developed severe disease. Th17 accumulation and development of EAE required IL-17A production by CD8 + T cells, suggesting that Tc17 cells are required to promote CD4+ T cell-mediated induction of EAE. Accordingly, patients with early-stage MS harbored a greater number of Tc17 cells in the cerebrospinal fluid than in peripheral blood. Our results reveal that Tc17 cells contribute to the initiation of CNS autoimmunity in mice and humans by supporting Th17 cell pathogenicity.
Persistent Identifierhttp://hdl.handle.net/10722/292047
ISSN
2023 Impact Factor: 13.3
2023 SCImago Journal Rankings: 4.833
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHuber, Magdalena-
dc.contributor.authorHeink, Sylvia-
dc.contributor.authorPagenstecher, Axel-
dc.contributor.authorReinhard, Katharina-
dc.contributor.authorRitter, Josephine-
dc.contributor.authorVisekruna, Alexander-
dc.contributor.authorGuralnik, Anna-
dc.contributor.authorBollig, Nadine-
dc.contributor.authorJeltsch, Katharina-
dc.contributor.authorHeinemann, Christina-
dc.contributor.authorWittmann, Eva-
dc.contributor.authorBuch, Thorsten-
dc.contributor.authorDa Costa, Olivia Prazeres-
dc.contributor.authorBrüstle, Anne-
dc.contributor.authorBrenner, Dirk-
dc.contributor.authorMak, Tak W.-
dc.contributor.authorMittrücker, Hans Willi-
dc.contributor.authorTackenberg, Björn-
dc.contributor.authorKamradt, Thomas-
dc.contributor.authorLohoff, Michael-
dc.date.accessioned2020-11-17T14:55:39Z-
dc.date.available2020-11-17T14:55:39Z-
dc.date.issued2013-
dc.identifier.citationJournal of Clinical Investigation, 2013, v. 123, n. 1, p. 247-260-
dc.identifier.issn0021-9738-
dc.identifier.urihttp://hdl.handle.net/10722/292047-
dc.description.abstractIL-17-producing CD8+ T (Tc17) cells are detectible in multiple sclerosis (MS) lesions; however, their contribution to the disease is unknown. To identify functions of Tc17 cells, we induced EAE, a murine model of MS, in mice lacking IFN regulatory factor 4 (IRF4). IRF4-deficient mice failed to generate Tc17 and Th17 cells and were resistant to EAE. After adoptive transfer of WT CD8+ T cells and subsequent immunization for EAE induction in these mice, the CD8+ T cells developed a Tc17 phenotype in the periphery but could not infiltrate the CNS. Similarly, transfer of small numbers of WT CD4+ T cells alone did not evoke EAE, but when transferred together with CD8+ T cells, IL-17-producing CD4+ (Th17) T cells accumulated in the CNS and mice developed severe disease. Th17 accumulation and development of EAE required IL-17A production by CD8 + T cells, suggesting that Tc17 cells are required to promote CD4+ T cell-mediated induction of EAE. Accordingly, patients with early-stage MS harbored a greater number of Tc17 cells in the cerebrospinal fluid than in peripheral blood. Our results reveal that Tc17 cells contribute to the initiation of CNS autoimmunity in mice and humans by supporting Th17 cell pathogenicity.-
dc.languageeng-
dc.relation.ispartofJournal of Clinical Investigation-
dc.titleIL-17A secretion by CD8<sup>+</sup> T cells supports Th17-mediated autoimmune encephalomyelitis-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1172/JCI63681-
dc.identifier.pmid23221338-
dc.identifier.pmcidPMC3533283-
dc.identifier.scopuseid_2-s2.0-84873825806-
dc.identifier.volume123-
dc.identifier.issue1-
dc.identifier.spage247-
dc.identifier.epage260-
dc.identifier.eissn1558-8238-
dc.identifier.isiWOS:000313598500030-
dc.identifier.f1000717973199-
dc.identifier.issnl0021-9738-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats