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- Publisher Website: 10.1074/jbc.M110.147371
- Scopus: eid_2-s2.0-79953003319
- PMID: 21097510
- WOS: WOS:000286975700008
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Article: DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-κB
Title | DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-κB |
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Authors | |
Issue Date | 2011 |
Citation | Journal of Biological Chemistry, 2011, v. 286, n. 6, p. 4098-4106 How to Cite? |
Abstract | Heightened DJ-1 (Park7) expression is associated with a reduction in chemotherapeutic-induced cell death and poor prognosis in several cancers, whereas the loss of DJ-1 function is found in a subgroup of Parkinson disease associated with neuronal death. This study describes a novel pathway by which DJ-1 modulates cell survival. Mass spectrometry shows that DJ-1 interacts with BBS1, CLCF1, MTREF, and Cezanne/ OTUD7B/Za20d1. Among these, Cezanne is a known deubiquitination enzyme that inhibits NF-κB activity. DJ-1/Cezanne interaction is confirmed by co-immunoprecipitation of overexpressed and endogenous proteins, maps to the amino-terminal 70 residues of DJ-1, and leads to the inhibition of the deubiquitinating activity of Cezanne. Microarray profiling of shRNA-transduced cells shows that DJ-1 and Cezanne regulate IL-8 and ICAM-1 expression in opposing directions. Similarly, DJ-1 enhances NF-κB nuclear translocation and cell survival, whereas Cezanne reduces these outcomes. Analysis of mouse Park7-/- primary cells confirms the regulation of ICAM-1 by DJ-1 and Cezanne. As NF-κB is important in cellular survival and transformation, IL-8 functions as an angiogenic factor and pro-survival signal, and ICAM-1 has been implicated in tumor progression, invasion, and metastasis; these data provide an additional modality by which DJ-1 controls cell survival and possibly tumor progression via interaction with Cezanne. © 2011 by The American Society for Biochemistry and Molecular Biology, Inc. |
Persistent Identifier | http://hdl.handle.net/10722/292021 |
ISSN | 2020 Impact Factor: 5.157 2023 SCImago Journal Rankings: 1.766 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | McNally, R. Sean | - |
dc.contributor.author | Davis, Beckley K. | - |
dc.contributor.author | Clements, Casey M. | - |
dc.contributor.author | Accavitti-Loper, Mary Ann | - |
dc.contributor.author | Mak, Tak W. | - |
dc.contributor.author | Ting, Jenny P.Y. | - |
dc.date.accessioned | 2020-11-17T14:55:36Z | - |
dc.date.available | 2020-11-17T14:55:36Z | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | Journal of Biological Chemistry, 2011, v. 286, n. 6, p. 4098-4106 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.uri | http://hdl.handle.net/10722/292021 | - |
dc.description.abstract | Heightened DJ-1 (Park7) expression is associated with a reduction in chemotherapeutic-induced cell death and poor prognosis in several cancers, whereas the loss of DJ-1 function is found in a subgroup of Parkinson disease associated with neuronal death. This study describes a novel pathway by which DJ-1 modulates cell survival. Mass spectrometry shows that DJ-1 interacts with BBS1, CLCF1, MTREF, and Cezanne/ OTUD7B/Za20d1. Among these, Cezanne is a known deubiquitination enzyme that inhibits NF-κB activity. DJ-1/Cezanne interaction is confirmed by co-immunoprecipitation of overexpressed and endogenous proteins, maps to the amino-terminal 70 residues of DJ-1, and leads to the inhibition of the deubiquitinating activity of Cezanne. Microarray profiling of shRNA-transduced cells shows that DJ-1 and Cezanne regulate IL-8 and ICAM-1 expression in opposing directions. Similarly, DJ-1 enhances NF-κB nuclear translocation and cell survival, whereas Cezanne reduces these outcomes. Analysis of mouse Park7-/- primary cells confirms the regulation of ICAM-1 by DJ-1 and Cezanne. As NF-κB is important in cellular survival and transformation, IL-8 functions as an angiogenic factor and pro-survival signal, and ICAM-1 has been implicated in tumor progression, invasion, and metastasis; these data provide an additional modality by which DJ-1 controls cell survival and possibly tumor progression via interaction with Cezanne. © 2011 by The American Society for Biochemistry and Molecular Biology, Inc. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of Biological Chemistry | - |
dc.title | DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-κB | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1074/jbc.M110.147371 | - |
dc.identifier.pmid | 21097510 | - |
dc.identifier.pmcid | PMC3039338 | - |
dc.identifier.scopus | eid_2-s2.0-79953003319 | - |
dc.identifier.volume | 286 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 4098 | - |
dc.identifier.epage | 4106 | - |
dc.identifier.eissn | 1083-351X | - |
dc.identifier.isi | WOS:000286975700008 | - |
dc.identifier.issnl | 0021-9258 | - |