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Article: Caspase 3 is not essential for the induction of anergy or multiple pathways of CD8+ T-cell death

TitleCaspase 3 is not essential for the induction of anergy or multiple pathways of CD8<sup>+</sup> T-cell death
Authors
KeywordsAnergy
T-cell tolerance
Clonal deletion
Caspase 3
Issue Date2010
Citation
European Journal of Immunology, 2010, v. 40, n. 12, p. 3372-3377 How to Cite?
AbstractT-cell death is a fundamental process that is intricately regulated at multiple phases during T-cell differentiation, tolerance induction and the decline of the immune response. Caspase 3 is a crucial molecule regulating both mitochondrial and death receptor apoptotic pathways and therefore we were interested in examining the role of caspase 3 in T cells. Using P14 and H-Y CD8+ TCR-transgenic models, our analysis has shown that caspase 3 is not required for thymic negative selection. In addition, caspase 3 does not play a prominent role in the contraction phase following acute viral infection, nor clonal deletion of CD8+ T cells under tolerizing conditions. Surprisingly, our studies demonstrate that caspase 3 was not required for the induction of CD8+ T-cell anergy in vivo, contrary to published reports using CD4+ T cells. Therefore, these results demonstrate that caspase 3 is not essential in CD8+ T cells for multiple forms of thymic or peripheral tolerance, nor the contraction phase after an acute anti-viral response. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Persistent Identifierhttp://hdl.handle.net/10722/292002
ISSN
2023 Impact Factor: 4.5
2023 SCImago Journal Rankings: 1.627
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMurakami, Kiichi-
dc.contributor.authorLiadis, Nicole-
dc.contributor.authorSarmiento, Janice-
dc.contributor.authorElford, Alisha R.-
dc.contributor.authorWoo, Minna-
dc.contributor.authorNguyen, Linh T.-
dc.contributor.authorMak, Tak W.-
dc.contributor.authorOhashi, Pamela S.-
dc.date.accessioned2020-11-17T14:55:34Z-
dc.date.available2020-11-17T14:55:34Z-
dc.date.issued2010-
dc.identifier.citationEuropean Journal of Immunology, 2010, v. 40, n. 12, p. 3372-3377-
dc.identifier.issn0014-2980-
dc.identifier.urihttp://hdl.handle.net/10722/292002-
dc.description.abstractT-cell death is a fundamental process that is intricately regulated at multiple phases during T-cell differentiation, tolerance induction and the decline of the immune response. Caspase 3 is a crucial molecule regulating both mitochondrial and death receptor apoptotic pathways and therefore we were interested in examining the role of caspase 3 in T cells. Using P14 and H-Y CD8+ TCR-transgenic models, our analysis has shown that caspase 3 is not required for thymic negative selection. In addition, caspase 3 does not play a prominent role in the contraction phase following acute viral infection, nor clonal deletion of CD8+ T cells under tolerizing conditions. Surprisingly, our studies demonstrate that caspase 3 was not required for the induction of CD8+ T-cell anergy in vivo, contrary to published reports using CD4+ T cells. Therefore, these results demonstrate that caspase 3 is not essential in CD8+ T cells for multiple forms of thymic or peripheral tolerance, nor the contraction phase after an acute anti-viral response. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.-
dc.languageeng-
dc.relation.ispartofEuropean Journal of Immunology-
dc.subjectAnergy-
dc.subjectT-cell tolerance-
dc.subjectClonal deletion-
dc.subjectCaspase 3-
dc.titleCaspase 3 is not essential for the induction of anergy or multiple pathways of CD8<sup>+</sup> T-cell death-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1002/eji.201040475-
dc.identifier.pmid21110320-
dc.identifier.scopuseid_2-s2.0-78649572347-
dc.identifier.volume40-
dc.identifier.issue12-
dc.identifier.spage3372-
dc.identifier.epage3377-
dc.identifier.eissn1521-4141-
dc.identifier.isiWOS:000285262200011-
dc.identifier.issnl0014-2980-

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