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Article: Identification of BERP (brain-expressed RING finger protein) as a p53 target gene that modulates seizure susceptibility through interacting with GABAA receptors

TitleIdentification of BERP (brain-expressed RING finger protein) as a p53 target gene that modulates seizure susceptibility through interacting with GABA<inf>A</inf> receptors
Authors
KeywordsTRIM3
Neurotransmitter
Brain
RNF22
Brat
Issue Date2010
Citation
Proceedings of the National Academy of Sciences of the United States of America, 2010, v. 107, n. 26, p. 11883-11888 How to Cite?
Abstractp53 is a central player in responses to cellular stresses and a major tumor suppressor. The identification of unique molecules within the p53 signaling network can reveal functions of this important transcription factor. Here, we show that brain-expressed RING finger protein (BERP) is a gene whose expression is up-regulated in a p53-dependent manner in human cells and in mice. We generated BERP-deficient mice by gene targeting and demonstrated that they exhibit increased resistance to pentylenetetrazol-induced seizures. Electrophysiological and biochemical studies of cultured cortical neurons of BERP-deficient mice showed a decrease in the amplitude of GABAA receptor (GABAAR)-mediated miniature inhibitory postsynaptic currents as well as reduced surface protein expression of GABAARs containing the γ2-subunit. However, BERP deficiency did not decrease GABA ARγ2 mRNA levels, raising the possibility that BERP may act at a posttranscriptional level to regulate the intracellular trafficking of GABAARs. Our results indicate that BERP is a unique p53-regulated gene and suggest a role for p53 within the central nervous system.
Persistent Identifierhttp://hdl.handle.net/10722/291979
ISSN
2023 Impact Factor: 9.4
2023 SCImago Journal Rankings: 3.737
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCheung, Carol C.-
dc.contributor.authorYang, Caimei-
dc.contributor.authorBerger, Thorsten-
dc.contributor.authorZaugg, Kathrin-
dc.contributor.authorReilly, Patrick-
dc.contributor.authorElia, Andrew J.-
dc.contributor.authorWakeham, Andrew-
dc.contributor.authorYou-Ten, Annick-
dc.contributor.authorChang, Ning-
dc.contributor.authorLi, Jun-
dc.contributor.authorWan, Qi-
dc.contributor.authorMak, Tak Wah-
dc.date.accessioned2020-11-17T14:55:31Z-
dc.date.available2020-11-17T14:55:31Z-
dc.date.issued2010-
dc.identifier.citationProceedings of the National Academy of Sciences of the United States of America, 2010, v. 107, n. 26, p. 11883-11888-
dc.identifier.issn0027-8424-
dc.identifier.urihttp://hdl.handle.net/10722/291979-
dc.description.abstractp53 is a central player in responses to cellular stresses and a major tumor suppressor. The identification of unique molecules within the p53 signaling network can reveal functions of this important transcription factor. Here, we show that brain-expressed RING finger protein (BERP) is a gene whose expression is up-regulated in a p53-dependent manner in human cells and in mice. We generated BERP-deficient mice by gene targeting and demonstrated that they exhibit increased resistance to pentylenetetrazol-induced seizures. Electrophysiological and biochemical studies of cultured cortical neurons of BERP-deficient mice showed a decrease in the amplitude of GABAA receptor (GABAAR)-mediated miniature inhibitory postsynaptic currents as well as reduced surface protein expression of GABAARs containing the γ2-subunit. However, BERP deficiency did not decrease GABA ARγ2 mRNA levels, raising the possibility that BERP may act at a posttranscriptional level to regulate the intracellular trafficking of GABAARs. Our results indicate that BERP is a unique p53-regulated gene and suggest a role for p53 within the central nervous system.-
dc.languageeng-
dc.relation.ispartofProceedings of the National Academy of Sciences of the United States of America-
dc.subjectTRIM3-
dc.subjectNeurotransmitter-
dc.subjectBrain-
dc.subjectRNF22-
dc.subjectBrat-
dc.titleIdentification of BERP (brain-expressed RING finger protein) as a p53 target gene that modulates seizure susceptibility through interacting with GABA<inf>A</inf> receptors-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1073/pnas.1006529107-
dc.identifier.pmid20543135-
dc.identifier.pmcidPMC2900672-
dc.identifier.scopuseid_2-s2.0-77955397905-
dc.identifier.volume107-
dc.identifier.issue26-
dc.identifier.spage11883-
dc.identifier.epage11888-
dc.identifier.eissn1091-6490-
dc.identifier.isiWOS:000279332300042-
dc.identifier.issnl0027-8424-

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