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Article: Nfil3/E4bp4 is required for the development and maturation of NK cells in vivo

TitleNfil3/E4bp4 is required for the development and maturation of NK cells in vivo
Authors
Issue Date2009
Citation
Journal of Experimental Medicine, 2009, v. 206, n. 13, p. 2977-2986 How to Cite?
AbstractNuclear factor interleukin-3 (Nfil3; also known as E4-binding protein 4) is a basic region leucine zipper transcription factor that has antiapoptotic activity in vitro under conditions of growth factor withdrawal. To study the role of Nfil3 in vivo, we generated gene-targeted Nfil3-deficient (Nfil3 -/-) mice. Nfil3-/- mice were born at normal Mendelian frequency and were grossly normal and fertile. Although numbers of T cells, B cells, and natural killer (NK) T cells were normal in Nfil3-/- mice, a specific disruption in NK cell development resulted in severely reduced numbers of mature NK cells in the periphery. This defect was NK cell intrinsic in nature, leading to a failure to reject MHC class I-deficient cells in vivo and reductions in both interferon γ production and cytolytic activity in vitro. Our results confirm the specific and essential requirement of Nfil3 for the development of cells of the NK lineage.
Persistent Identifierhttp://hdl.handle.net/10722/291937
ISSN
2023 Impact Factor: 12.6
2023 SCImago Journal Rankings: 6.838
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKamizono, Shintaro-
dc.contributor.authorDuncan, Gordon S.-
dc.contributor.authorSeidel, Markus G.-
dc.contributor.authorMorimoto, Akira-
dc.contributor.authorHamada, Koichi-
dc.contributor.authorGrosveld, Gerard-
dc.contributor.authorAkashi, Koichi-
dc.contributor.authorLind, Evan F.-
dc.contributor.authorHaight, Jillian P.-
dc.contributor.authorOhashi, Pamela S.-
dc.contributor.authorLook, A. Thomas-
dc.contributor.authorMak, Tak W.-
dc.date.accessioned2020-11-17T14:55:25Z-
dc.date.available2020-11-17T14:55:25Z-
dc.date.issued2009-
dc.identifier.citationJournal of Experimental Medicine, 2009, v. 206, n. 13, p. 2977-2986-
dc.identifier.issn0022-1007-
dc.identifier.urihttp://hdl.handle.net/10722/291937-
dc.description.abstractNuclear factor interleukin-3 (Nfil3; also known as E4-binding protein 4) is a basic region leucine zipper transcription factor that has antiapoptotic activity in vitro under conditions of growth factor withdrawal. To study the role of Nfil3 in vivo, we generated gene-targeted Nfil3-deficient (Nfil3 -/-) mice. Nfil3-/- mice were born at normal Mendelian frequency and were grossly normal and fertile. Although numbers of T cells, B cells, and natural killer (NK) T cells were normal in Nfil3-/- mice, a specific disruption in NK cell development resulted in severely reduced numbers of mature NK cells in the periphery. This defect was NK cell intrinsic in nature, leading to a failure to reject MHC class I-deficient cells in vivo and reductions in both interferon γ production and cytolytic activity in vitro. Our results confirm the specific and essential requirement of Nfil3 for the development of cells of the NK lineage.-
dc.languageeng-
dc.relation.ispartofJournal of Experimental Medicine-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleNfil3/E4bp4 is required for the development and maturation of NK cells in vivo-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1084/jem.20092176-
dc.identifier.pmid19995955-
dc.identifier.pmcidPMC2806474-
dc.identifier.scopuseid_2-s2.0-73949134616-
dc.identifier.volume206-
dc.identifier.issue13-
dc.identifier.spage2977-
dc.identifier.epage2986-
dc.identifier.eissn1540-9538-
dc.identifier.isiWOS:000272987500015-
dc.identifier.issnl0022-1007-

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