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Article: Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies

TitleAdjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies
Authors
Issue Date2009
Citation
Nature Medicine, 2009, v. 15, n. 5, p. 528-536 How to Cite?
AbstractIdentifying key factors that enhance immune responses is crucial for manipulating immunity to tumors. We show that after a vaccine-induced immune response, adjuvant interleukin-7 (IL-7) improves antitumor responses and survival in an animal model. The improved immune response is associated with increased IL-6 production and augmented T helper type 17 cell differentiation. Furthermore, IL-7 modulates the expression of two ubiquitin ligases: Casitas B-lineage lymphoma b (Cbl-b), a negative regulator of T cell activation, is repressed, and SMAD-specific E3 ubiquitin protein ligase-2 (Smurf2) is enhanced, which antagonizes transforming growth factor-Β signaling. Notably, we show that although short term IL-7 therapy potently enhances vaccine-mediated immunity, in the absence of vaccination it is inefficient in promoting antitumor immune responses, despite inducing homeostatic proliferation of T cells. The ability of adjuvant IL-7 to antagonize inhibitory networks at the cellular and molecular level has major implications for immunotherapy in the treatment of tumors.
Persistent Identifierhttp://hdl.handle.net/10722/291900
ISSN
2023 Impact Factor: 58.7
2023 SCImago Journal Rankings: 19.045
ISI Accession Number ID
Errata

 

DC FieldValueLanguage
dc.contributor.authorPellegrini, Marc-
dc.contributor.authorCalzascia, Thomas-
dc.contributor.authorElford, Alisha R.-
dc.contributor.authorShahinian, Arda-
dc.contributor.authorLin, Amy E.-
dc.contributor.authorDissanayake, Dilan-
dc.contributor.authorDhanji, Salim-
dc.contributor.authorNguyen, Linh T.-
dc.contributor.authorGronski, Matthew A.-
dc.contributor.authorMorre, Michel-
dc.contributor.authorAssouline, Brigitte-
dc.contributor.authorLahl, Katharina-
dc.contributor.authorSparwasser, Tim-
dc.contributor.authorOhashi, Pamela S.-
dc.contributor.authorMak, Tak W.-
dc.date.accessioned2020-11-17T14:55:21Z-
dc.date.available2020-11-17T14:55:21Z-
dc.date.issued2009-
dc.identifier.citationNature Medicine, 2009, v. 15, n. 5, p. 528-536-
dc.identifier.issn1078-8956-
dc.identifier.urihttp://hdl.handle.net/10722/291900-
dc.description.abstractIdentifying key factors that enhance immune responses is crucial for manipulating immunity to tumors. We show that after a vaccine-induced immune response, adjuvant interleukin-7 (IL-7) improves antitumor responses and survival in an animal model. The improved immune response is associated with increased IL-6 production and augmented T helper type 17 cell differentiation. Furthermore, IL-7 modulates the expression of two ubiquitin ligases: Casitas B-lineage lymphoma b (Cbl-b), a negative regulator of T cell activation, is repressed, and SMAD-specific E3 ubiquitin protein ligase-2 (Smurf2) is enhanced, which antagonizes transforming growth factor-Β signaling. Notably, we show that although short term IL-7 therapy potently enhances vaccine-mediated immunity, in the absence of vaccination it is inefficient in promoting antitumor immune responses, despite inducing homeostatic proliferation of T cells. The ability of adjuvant IL-7 to antagonize inhibitory networks at the cellular and molecular level has major implications for immunotherapy in the treatment of tumors.-
dc.languageeng-
dc.relation.ispartofNature Medicine-
dc.titleAdjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/nm.1953-
dc.identifier.pmid19396174-
dc.identifier.scopuseid_2-s2.0-67349193717-
dc.identifier.volume15-
dc.identifier.issue5-
dc.identifier.spage528-
dc.identifier.epage536-
dc.identifier.eissn1546-170X-
dc.identifier.isiWOS:000265889300031-
dc.relation.erratumdoi:10.1038/nm0709-819b-
dc.relation.erratumeid:eid_2-s2.0-67650467701-
dc.identifier.issnl1078-8956-

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