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Article: Noncanonical NF-κB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK

TitleNoncanonical NF-κB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK
Authors
Issue Date2008
Citation
Nature Immunology, 2008, v. 9, n. 12, p. 1371-1378 How to Cite?
AbstractRecent studies suggest that nuclear factor κB-inducing kinase (NIK) is suppressed through constitutive proteasome-mediated degradation regulated by TRAF2, TRAF3 and cIAP1 or cIAP2. Here we demonstrated that the degradation of NIK occurs upon assembly of a regulatory complex through TRAF3 recruitment of NIK and TRAF2 recruitment of cIAP1 and cIAP2. In contrast to TRAF2 and TRAF3, cIAP1 and cIAP2 seem to play redundant roles in the degradation of NIK, as inhibition of both cIAPs was required for noncanonical NF-κB activation and increased survival and proliferation of primary B lymphocytes. Furthermore, the lethality of TRAF3 deficiency in mice could be rescued by a single NIK gene, highlighting the importance of tightly regulated NIK.
Persistent Identifierhttp://hdl.handle.net/10722/291868
ISSN
2023 Impact Factor: 27.7
2023 SCImago Journal Rankings: 11.274
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZarnegar, Brian J.-
dc.contributor.authorWang, Yaya-
dc.contributor.authorMahoney, Douglas J.-
dc.contributor.authorDempsey, Paul W.-
dc.contributor.authorCheung, Herman H.-
dc.contributor.authorHe, Jeannie-
dc.contributor.authorShiba, Travis-
dc.contributor.authorYang, Xiaolu-
dc.contributor.authorYeh, Wen Chen-
dc.contributor.authorMak, Tak W.-
dc.contributor.authorKorneluk, Robert G.-
dc.contributor.authorCheng, Genhong-
dc.date.accessioned2020-11-17T14:55:17Z-
dc.date.available2020-11-17T14:55:17Z-
dc.date.issued2008-
dc.identifier.citationNature Immunology, 2008, v. 9, n. 12, p. 1371-1378-
dc.identifier.issn1529-2908-
dc.identifier.urihttp://hdl.handle.net/10722/291868-
dc.description.abstractRecent studies suggest that nuclear factor κB-inducing kinase (NIK) is suppressed through constitutive proteasome-mediated degradation regulated by TRAF2, TRAF3 and cIAP1 or cIAP2. Here we demonstrated that the degradation of NIK occurs upon assembly of a regulatory complex through TRAF3 recruitment of NIK and TRAF2 recruitment of cIAP1 and cIAP2. In contrast to TRAF2 and TRAF3, cIAP1 and cIAP2 seem to play redundant roles in the degradation of NIK, as inhibition of both cIAPs was required for noncanonical NF-κB activation and increased survival and proliferation of primary B lymphocytes. Furthermore, the lethality of TRAF3 deficiency in mice could be rescued by a single NIK gene, highlighting the importance of tightly regulated NIK.-
dc.languageeng-
dc.relation.ispartofNature Immunology-
dc.titleNoncanonical NF-κB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/ni.1676-
dc.identifier.pmid18997794-
dc.identifier.scopuseid_2-s2.0-56349164239-
dc.identifier.volume9-
dc.identifier.issue12-
dc.identifier.spage1371-
dc.identifier.epage1378-
dc.identifier.eissn1529-2916-
dc.identifier.isiWOS:000260888700012-
dc.identifier.issnl1529-2908-

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