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Article: Fas Receptor Expression in Germinal-Center B Cells Is Essential for T and B Lymphocyte Homeostasis

TitleFas Receptor Expression in Germinal-Center B Cells Is Essential for T and B Lymphocyte Homeostasis
Authors
KeywordsCELLIMMUNO
Issue Date2008
Citation
Immunity, 2008, v. 29, n. 4, p. 615-627 How to Cite?
AbstractFas is highly expressed in activated and germinal center (GC) B cells but can potentially be inactivated by misguided somatic hypermutation. We employed conditional Fas-deficient mice to investigate the physiological functions of Fas in various B cell subsets. B cell-specific Fas-deficient mice developed fatal lymphoproliferation due to activation of B cells and T cells. Ablation of Fas specifically in GC B cells reproduced the phenotype, indicating that the lymphoproliferation initiates in the GC environment. B cell-specific Fas-deficient mice also showed an accumulation of IgG1+ memory B cells expressing high amounts of CD80 and the expansion of CD28-expressing CD4+ Th cells. Blocking T cell-B cell interaction and GC formation completely prevented the fatal lymphoproliferation. Thus, Fas-mediated selection of GC B cells and the resulting memory B cell compartment is essential for maintaining the homeostasis of both T and B lymphocytes. © 2008 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/291859
ISSN
2022 Impact Factor: 32.4
2020 SCImago Journal Rankings: 14.286
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHao, Zhenyue-
dc.contributor.authorDuncan, Gordon S.-
dc.contributor.authorSeagal, Jane-
dc.contributor.authorSu, Yu Wen-
dc.contributor.authorHong, Claire-
dc.contributor.authorHaight, Jillian-
dc.contributor.authorChen, Nien Jung-
dc.contributor.authorElia, Andrew-
dc.contributor.authorWakeham, Andrew-
dc.contributor.authorLi, Wanda Y.-
dc.contributor.authorLiepa, Jennifer-
dc.contributor.authorWood, Geoffrey A.-
dc.contributor.authorCasola, Stefano-
dc.contributor.authorRajewsky, Klaus-
dc.contributor.authorMak, Tak W.-
dc.date.accessioned2020-11-17T14:55:16Z-
dc.date.available2020-11-17T14:55:16Z-
dc.date.issued2008-
dc.identifier.citationImmunity, 2008, v. 29, n. 4, p. 615-627-
dc.identifier.issn1074-7613-
dc.identifier.urihttp://hdl.handle.net/10722/291859-
dc.description.abstractFas is highly expressed in activated and germinal center (GC) B cells but can potentially be inactivated by misguided somatic hypermutation. We employed conditional Fas-deficient mice to investigate the physiological functions of Fas in various B cell subsets. B cell-specific Fas-deficient mice developed fatal lymphoproliferation due to activation of B cells and T cells. Ablation of Fas specifically in GC B cells reproduced the phenotype, indicating that the lymphoproliferation initiates in the GC environment. B cell-specific Fas-deficient mice also showed an accumulation of IgG1+ memory B cells expressing high amounts of CD80 and the expansion of CD28-expressing CD4+ Th cells. Blocking T cell-B cell interaction and GC formation completely prevented the fatal lymphoproliferation. Thus, Fas-mediated selection of GC B cells and the resulting memory B cell compartment is essential for maintaining the homeostasis of both T and B lymphocytes. © 2008 Elsevier Inc. All rights reserved.-
dc.languageeng-
dc.relation.ispartofImmunity-
dc.subjectCELLIMMUNO-
dc.titleFas Receptor Expression in Germinal-Center B Cells Is Essential for T and B Lymphocyte Homeostasis-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/j.immuni.2008.07.016-
dc.identifier.pmid18835195-
dc.identifier.pmcidPMC3470429-
dc.identifier.scopuseid_2-s2.0-53349167095-
dc.identifier.volume29-
dc.identifier.issue4-
dc.identifier.spage615-
dc.identifier.epage627-
dc.identifier.isiWOS:000260316700014-
dc.identifier.f10001147356-
dc.identifier.issnl1074-7613-

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