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Article: Experimental manipulation of radiographic density in mouse mammary gland

TitleExperimental manipulation of radiographic density in mouse mammary gland
Authors
KeywordsRadiography
Mammography
Mouse model
Mammographic density
Breast cancer
Issue Date2004
Citation
Breast Cancer Research, 2004, v. 6, n. 5, p. R540-R545 How to Cite?
AbstractIntroduction: Extensive mammographic density in women is associated with increased risk for breast cancer. Mouse models provide a powerful approach to the study of human diseases, but there is currently no model that is suited to the study of mammographic density. Methods: We performed individual manipulations of the stromal, epithelial and matrix components of the mouse mammary gland and examined the alterations using in vivo and ex vivo radiology, whole mount staining and histology. Results: Areas of density were generated that resembled densities in mammographic images of the human breast, and the nature of the imposed changes was confirmed at the cellular level. Furthermore, two genetic models, one deficient in epithelial structure (Pten conditional tissue specific knockout) and one with hyperplastic epithelium and mammary tumors (MMTV-PyMT), were used to examine radiographic density. Conclusion: Our data show the feasibility of altering and imaging mouse mammary gland radiographic density by experimental and genetic means, providing the first step toward modelling the biological processes that are responsible for mammographic density in the mouse.
Persistent Identifierhttp://hdl.handle.net/10722/291836
ISSN
2023 Impact Factor: 6.1
2023 SCImago Journal Rankings: 2.578
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHariri, Mehrdad-
dc.contributor.authorWood, Geoffrey A.-
dc.contributor.authorDiGrappa, Marco A.-
dc.contributor.authorMacPherson, Michelle-
dc.contributor.authorBackman, Stephanie A.-
dc.contributor.authorYaffe, Martin J.-
dc.contributor.authorMak, Tak W.-
dc.contributor.authorBoyd, Norman F.-
dc.contributor.authorKhokha, Rama-
dc.date.accessioned2020-11-17T14:55:13Z-
dc.date.available2020-11-17T14:55:13Z-
dc.date.issued2004-
dc.identifier.citationBreast Cancer Research, 2004, v. 6, n. 5, p. R540-R545-
dc.identifier.issn1465-5411-
dc.identifier.urihttp://hdl.handle.net/10722/291836-
dc.description.abstractIntroduction: Extensive mammographic density in women is associated with increased risk for breast cancer. Mouse models provide a powerful approach to the study of human diseases, but there is currently no model that is suited to the study of mammographic density. Methods: We performed individual manipulations of the stromal, epithelial and matrix components of the mouse mammary gland and examined the alterations using in vivo and ex vivo radiology, whole mount staining and histology. Results: Areas of density were generated that resembled densities in mammographic images of the human breast, and the nature of the imposed changes was confirmed at the cellular level. Furthermore, two genetic models, one deficient in epithelial structure (Pten conditional tissue specific knockout) and one with hyperplastic epithelium and mammary tumors (MMTV-PyMT), were used to examine radiographic density. Conclusion: Our data show the feasibility of altering and imaging mouse mammary gland radiographic density by experimental and genetic means, providing the first step toward modelling the biological processes that are responsible for mammographic density in the mouse.-
dc.languageeng-
dc.relation.ispartofBreast Cancer Research-
dc.rights© 2004 Hariri et al.; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.-
dc.subjectRadiography-
dc.subjectMammography-
dc.subjectMouse model-
dc.subjectMammographic density-
dc.subjectBreast cancer-
dc.titleExperimental manipulation of radiographic density in mouse mammary gland-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/bcr901-
dc.identifier.pmid15318935-
dc.identifier.pmcidPMC549169-
dc.identifier.scopuseid_2-s2.0-4644253899-
dc.identifier.volume6-
dc.identifier.issue5-
dc.identifier.spageR540-
dc.identifier.epageR545-
dc.identifier.eissn1465-542X-
dc.identifier.isiWOS:000223866400014-
dc.identifier.issnl1465-5411-

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