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Article: Soluble Interleukin-13Rα2 Decoy Receptor Inhibits Hodgkin's Lymphoma Growth in Vitro and in Vivo

TitleSoluble Interleukin-13Rα2 Decoy Receptor Inhibits Hodgkin's Lymphoma Growth in Vitro and in Vivo
Authors
Issue Date2004
Citation
Cancer Research, 2004, v. 64, n. 9, p. 3271-3275 How to Cite?
AbstractRecent studies have demonstrated that the malignant Reed-Sternberg cells of Hodgkin's lymphoma (HL) secrete and are responsive to interleukin (IL)-13. We hypothesized that overexpression of a soluble IL-13 decoy receptor (sIL-13Rα2) via adenoviral-mediated gene transfer would inhibit IL-13-induced Reed-Sternberg cell proliferation. Western blot and ELISA analysis verified expression of sIL-13Rα2 in cell lysates and supernatants of AdsIL-13Rα2-transduced COS-7 cells. Treatment of two IL-13-responsive HL-derived cell lines, HDLM-2 and L-1236, with AdsIL-13Rα2-conditioned medium, resulted in the inhibition of cell proliferation, and down-regulated the phosphorylation of signal transducer and activator of transcription 6 (STAT6), an important mediator of IL-13 signaling. i.v. delivery of AdsIL-13Rα2 in NOD/SCID mice with s.c. implanted HDLM-2 cells delayed tumor onset and growth while enhancing survival compared with control mice. Intratumoral administration of AdsIL-13Rα2 led to the regression or stabilization of established tumors and was associated with diminished STAT6 phosphorylation. Our data demonstrate that AdsIL-13Rα2 can suppress HL growth in vitro and in vivo.
Persistent Identifierhttp://hdl.handle.net/10722/291741
ISSN
2023 Impact Factor: 12.5
2023 SCImago Journal Rankings: 3.468
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTrieu, Young-
dc.contributor.authorWen, Xiao Yan-
dc.contributor.authorSkinnider, Brian F.-
dc.contributor.authorBray, Mark R.-
dc.contributor.authorLi, Zhihua-
dc.contributor.authorClaudio, Jaime O.-
dc.contributor.authorMasih-Khan, Esther-
dc.contributor.authorZhu, Yuan Xiao-
dc.contributor.authorTrudel, Suzanne-
dc.contributor.authorMcCart, J. Andrea-
dc.contributor.authorMak, Tak W.-
dc.contributor.authorStewart, A. Keith-
dc.date.accessioned2020-11-17T14:55:01Z-
dc.date.available2020-11-17T14:55:01Z-
dc.date.issued2004-
dc.identifier.citationCancer Research, 2004, v. 64, n. 9, p. 3271-3275-
dc.identifier.issn0008-5472-
dc.identifier.urihttp://hdl.handle.net/10722/291741-
dc.description.abstractRecent studies have demonstrated that the malignant Reed-Sternberg cells of Hodgkin's lymphoma (HL) secrete and are responsive to interleukin (IL)-13. We hypothesized that overexpression of a soluble IL-13 decoy receptor (sIL-13Rα2) via adenoviral-mediated gene transfer would inhibit IL-13-induced Reed-Sternberg cell proliferation. Western blot and ELISA analysis verified expression of sIL-13Rα2 in cell lysates and supernatants of AdsIL-13Rα2-transduced COS-7 cells. Treatment of two IL-13-responsive HL-derived cell lines, HDLM-2 and L-1236, with AdsIL-13Rα2-conditioned medium, resulted in the inhibition of cell proliferation, and down-regulated the phosphorylation of signal transducer and activator of transcription 6 (STAT6), an important mediator of IL-13 signaling. i.v. delivery of AdsIL-13Rα2 in NOD/SCID mice with s.c. implanted HDLM-2 cells delayed tumor onset and growth while enhancing survival compared with control mice. Intratumoral administration of AdsIL-13Rα2 led to the regression or stabilization of established tumors and was associated with diminished STAT6 phosphorylation. Our data demonstrate that AdsIL-13Rα2 can suppress HL growth in vitro and in vivo.-
dc.languageeng-
dc.relation.ispartofCancer Research-
dc.titleSoluble Interleukin-13Rα2 Decoy Receptor Inhibits Hodgkin's Lymphoma Growth in Vitro and in Vivo-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1158/0008-5472.CAN-03-3764-
dc.identifier.pmid15126369-
dc.identifier.scopuseid_2-s2.0-2342541843-
dc.identifier.volume64-
dc.identifier.issue9-
dc.identifier.spage3271-
dc.identifier.epage3275-
dc.identifier.isiWOS:000221150500046-
dc.identifier.issnl0008-5472-

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