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Article: Duration of TCR stimulation determines costimulatory requirement of T cells

TitleDuration of TCR stimulation determines costimulatory requirement of T cells
Authors
Issue Date1996
Citation
Immunity, 1996, v. 5, n. 1, p. 41-52 How to Cite?
AbstractCurrent models suggest that T cells that receive only signal-1 through antigenic stimulation of the T cell receptor (TCR) become anergic, but will mount an immune response when a costimulatory signal-2 is provided. Using mice deficient for an important costimulatory molecule, CD28, we show that a transient signal-1 alone, either through infection with an abortively replicating virus, or through injection of viral peptide, energizes CD8+ T cells, demonstrating the biological relevance of T cell anergy in vivo. However, in the absence of CD28, continued presence of signal-1 alone, either through prolonged viral replication or repeated injection of peptide, prevents the induction of anergy and generates a functional T cell response in vivo.
Persistent Identifierhttp://hdl.handle.net/10722/291721
ISSN
2023 Impact Factor: 25.5
2023 SCImago Journal Rankings: 13.578
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKündig, Thomas M.-
dc.contributor.authorShahinian, Arda-
dc.contributor.authorKawai, Kazuhiro-
dc.contributor.authorMittrücker, Hans Willi-
dc.contributor.authorSebzda, Eric-
dc.contributor.authorBachmann, Martin F.-
dc.contributor.authorMak, Tak W.-
dc.contributor.authorOhashi, Pamela S.-
dc.date.accessioned2020-11-17T14:54:59Z-
dc.date.available2020-11-17T14:54:59Z-
dc.date.issued1996-
dc.identifier.citationImmunity, 1996, v. 5, n. 1, p. 41-52-
dc.identifier.issn1074-7613-
dc.identifier.urihttp://hdl.handle.net/10722/291721-
dc.description.abstractCurrent models suggest that T cells that receive only signal-1 through antigenic stimulation of the T cell receptor (TCR) become anergic, but will mount an immune response when a costimulatory signal-2 is provided. Using mice deficient for an important costimulatory molecule, CD28, we show that a transient signal-1 alone, either through infection with an abortively replicating virus, or through injection of viral peptide, energizes CD8+ T cells, demonstrating the biological relevance of T cell anergy in vivo. However, in the absence of CD28, continued presence of signal-1 alone, either through prolonged viral replication or repeated injection of peptide, prevents the induction of anergy and generates a functional T cell response in vivo.-
dc.languageeng-
dc.relation.ispartofImmunity-
dc.titleDuration of TCR stimulation determines costimulatory requirement of T cells-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/S1074-7613(00)80308-8-
dc.identifier.pmid8758893-
dc.identifier.scopuseid_2-s2.0-1842373718-
dc.identifier.volume5-
dc.identifier.issue1-
dc.identifier.spage41-
dc.identifier.epage52-
dc.identifier.isiWOS:A1996UZ45400005-
dc.identifier.issnl1074-7613-

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