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Article: WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection

TitleWSX-1 is required for the initiation of Th1 responses and resistance to L. major infection
Authors
Issue Date2001
Citation
Immunity, 2001, v. 15, n. 4, p. 569-578 How to Cite?
AbstractWSX-1 is a class I cytokine receptor with homology to the IL-12 receptors. The physiological role of WSX-1, which is expressed mainly in T cells, was investigated in gene-targeted WSX-1-deficient mice. IFN-γ production was reduced in isolated WSX-1-/- T cells subjected to primary stimulation in vitro to induce Th1 differentiation but was normal in fully differentiated and activated WSX-1-/- Th1 cells that had received secondary stimulation. WSX-1-/- mice were remarkably susceptible to Leishmania major infection, showing impaired IFN-γ production early in the infection. However, IFN-γ production during the later phases of the infection was not impaired in the knockout. WSX-1-/- mice also showed poorly differentiated granulomas with dispersed accumulations of mononuclear cells when infected with bacillus Calmette-Guerin (BCG). Thus, WSX-1 is essential for the initial mounting of Th1 responses but dispensable for their maintenance.
Persistent Identifierhttp://hdl.handle.net/10722/291715
ISSN
2023 Impact Factor: 25.5
2023 SCImago Journal Rankings: 13.578
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYoshida, Hiroki-
dc.contributor.authorHamano, Shinjiro-
dc.contributor.authorSenaldi, Giorgio-
dc.contributor.authorCovey, Todd-
dc.contributor.authorFaggioni, Raffaella-
dc.contributor.authorMu, Sharon-
dc.contributor.authorXia, Min-
dc.contributor.authorWakeham, Andrew C.-
dc.contributor.authorNishina, Hiroshi-
dc.contributor.authorPotter, Julia-
dc.contributor.authorSaris, Chris J.M.-
dc.contributor.authorMak, Tak W.-
dc.date.accessioned2020-11-17T14:54:57Z-
dc.date.available2020-11-17T14:54:57Z-
dc.date.issued2001-
dc.identifier.citationImmunity, 2001, v. 15, n. 4, p. 569-578-
dc.identifier.issn1074-7613-
dc.identifier.urihttp://hdl.handle.net/10722/291715-
dc.description.abstractWSX-1 is a class I cytokine receptor with homology to the IL-12 receptors. The physiological role of WSX-1, which is expressed mainly in T cells, was investigated in gene-targeted WSX-1-deficient mice. IFN-γ production was reduced in isolated WSX-1-/- T cells subjected to primary stimulation in vitro to induce Th1 differentiation but was normal in fully differentiated and activated WSX-1-/- Th1 cells that had received secondary stimulation. WSX-1-/- mice were remarkably susceptible to Leishmania major infection, showing impaired IFN-γ production early in the infection. However, IFN-γ production during the later phases of the infection was not impaired in the knockout. WSX-1-/- mice also showed poorly differentiated granulomas with dispersed accumulations of mononuclear cells when infected with bacillus Calmette-Guerin (BCG). Thus, WSX-1 is essential for the initial mounting of Th1 responses but dispensable for their maintenance.-
dc.languageeng-
dc.relation.ispartofImmunity-
dc.titleWSX-1 is required for the initiation of Th1 responses and resistance to L. major infection-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/S1074-7613(01)00206-0-
dc.identifier.pmid11672539-
dc.identifier.scopuseid_2-s2.0-17944377950-
dc.identifier.volume15-
dc.identifier.issue4-
dc.identifier.spage569-
dc.identifier.epage578-
dc.identifier.isiWOS:000171757800008-
dc.identifier.f10001003805-
dc.identifier.issnl1074-7613-

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