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Article: Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function

TitleRequirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function
Authors
Issue Date1997
Citation
Science, 1997, v. 275, n. 5299, p. 540-543 How to Cite?
AbstractLymphocyte-specific interferon regulatory factor (LSIRF) (now called IRF4) is a transcription factor expressed only in lymphocytes. Mice deficient in IRF4 showed normal distribution of B and T lymphocyes at 4 to 5 weeks of age but developed progressive generalized lymphadenopathy. IRF4-deficient mice exhibited a profound reduction in serum immunoglobulin concentrations and did not mount detectable antibody responses. T lymphocyte function was also impaired in vivo; these mice could not generate cytotoxic or antitumor responses. Thus, IRF4 is essential for the function and homeostasis of both mature B and mature T lymphocytes.
Persistent Identifierhttp://hdl.handle.net/10722/291697
ISSN
2023 Impact Factor: 44.7
2023 SCImago Journal Rankings: 11.902
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMittrücker, Hans Willi-
dc.contributor.authorMatsuyama, Toshifumi-
dc.contributor.authorGrossman, Alex-
dc.contributor.authorKündig, Thomas M.-
dc.contributor.authorPotter, Julia-
dc.contributor.authorShahinian, Arda-
dc.contributor.authorWakeham, Andrew-
dc.contributor.authorPatterson, Bruce-
dc.contributor.authorOhashi, Pamela S.-
dc.contributor.authorMak, Tak W.-
dc.date.accessioned2020-11-17T14:54:55Z-
dc.date.available2020-11-17T14:54:55Z-
dc.date.issued1997-
dc.identifier.citationScience, 1997, v. 275, n. 5299, p. 540-543-
dc.identifier.issn0036-8075-
dc.identifier.urihttp://hdl.handle.net/10722/291697-
dc.description.abstractLymphocyte-specific interferon regulatory factor (LSIRF) (now called IRF4) is a transcription factor expressed only in lymphocytes. Mice deficient in IRF4 showed normal distribution of B and T lymphocyes at 4 to 5 weeks of age but developed progressive generalized lymphadenopathy. IRF4-deficient mice exhibited a profound reduction in serum immunoglobulin concentrations and did not mount detectable antibody responses. T lymphocyte function was also impaired in vivo; these mice could not generate cytotoxic or antitumor responses. Thus, IRF4 is essential for the function and homeostasis of both mature B and mature T lymphocytes.-
dc.languageeng-
dc.relation.ispartofScience-
dc.titleRequirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1126/science.275.5299.540-
dc.identifier.pmid8999800-
dc.identifier.scopuseid_2-s2.0-15444346834-
dc.identifier.volume275-
dc.identifier.issue5299-
dc.identifier.spage540-
dc.identifier.epage543-
dc.identifier.isiWOS:000415967800002-
dc.identifier.issnl0036-8075-

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